Browsing by Author "O'Neill, Luke"
Now showing items 1-20 of 56
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A role for eIF4A1 in IL-10 induction by LPS
Alam, M. Mustafa (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)microRNAs are a family of short non-coding RNAs that act as fine tuners of gene expression by controlling mRNAs. They have been implicated in numerous diseases including inflammatory diseases. A number of studies have ... -
A role for microRNA-21 in the regulation of gastrointestinal health and disease
Johnston, Daniel (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)The gastrointestinal (GI) tract is a crucial site of innate and adaptive immune regulation, balancing tolerance of beneficial commensal microorganisms and reaction to invading pathgens. Pattern recognition receptors (PRRs), ... -
An investigation into novel components and signalling mechanisms of inflammasomes
Becker, Christine (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)This thesis concerns an analysis of caspase-1 and ASC, key components of the inflammasome. At the outset Rab39a had been found in a complex with caspase-1. Rab39a is a member of the Rab GTPase family, a group of proteins ... -
An investigation into the role of TLR4 interactor with leucine rich repeats (TRIL) in Toll-like receptor responses in brain
Wochal, Paulina (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)TLR4 interactor with leucine rich repeats (TRIL) was originally described as a protein required for Toll-like receptor 4 (TLR4) signalling. This thesis provides new insights into the function of TRIL within TLR signalling ... -
An investigation into the role of TMED1 in IL-33/ST2L singalling pathway
Connolly, Dympna (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)This thesis set out to characterise the GOLD domain containing protein, TMED1 which had been shown to associate with ST2L, the receptor for the cytokine IL-33 and to investigate its relationship with ST2L. -
Analysis of the role of Krebs cycle rewiring in macrophage cytokine production
RYAN, DYLAN GERARD (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell activation. Multiple immune receptor types rewire metabolic pathways ... -
The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK
Lynch, Marina; Lynch, Aileen; Kelly, Aine; O'Neill, Luke (2001)Several effects of the proinflammatory cytokine, interleukin-1? (IL-1?), have been described in the central nervous system, and one area of the brain where marked changes have been reported is the hippocampus. Among these ... -
Author Correction: A guiding map for inflammation (Nature Immunology, (2017), 18, 8, (826-831), 10.1038/ni.3790)
Mills, Kingston; O'Neill, Luke (2021) -
Bridging the gap – a new role for STAT3 in TLR4-mediated metabolic reprogramming
O'Neill, Luke (2021)In this article, we discuss a new study from the laboratory of Ashley Mansell that successfully links innate immune receptor signaling to metabolic changes in macrophages, establishing for the first time an uninterrupted ... -
Caspase-11 promotes allergic airway inflammation
Creagh, Emma; Lavelle, Edward; O'Neill, Luke; Mills, Kingston; Zasłona, Zbigniew; Flis, Ewelina; Wilk, Mieszko M.; Carroll, Richard G.; Palsson-McDermott, Eva M.; Hughes, Mark M.; Diskin, Ciana; Banahan, Kathy; Ryan, Dylan G.; Hooftman, Alexander; Misiak, Alicja; Kearney, Jay; Lochnit, Gunter; Bertrams, Wilhelm; Greulich, Timm; Schmeck, Bernd; McElvaney, Oliver J.; Wygrecka, Małgorzata (2020)Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 ... -
Characterisation of signalling pathways activated by the IL-1 receptor homologue T1/ST2
Brint, Elizabeth (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2003)T1/ST2 is a member of the IL-1 receptor family possessing the three characteristic extracellular Ig domains and an intracellular Toll-IL1R (TIR) domain. It is an orphan receptor expressed on a variety of cell types including ... -
Characterisation of the novel leucine rich repeat containing protein KIAA0644
Carpenter, Susan (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)This thesis reports the existence o f a novel leucine rich repeat containing protein annotated as KIAA0644 in the Kazusa DNA Research Institute database (www.Kazusa.or.jp). which was discovered in a study for proteins ... -
Characterisation of the role of Bruton's tyrosine kinase in toll-like receptor signalling
Doyle, Sarah (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)Toll-like receptors (TLRs) are the primary surveillance system for the detection of pathogens and are crucial to the activation of the host innate response. TLRs contain an extracellular leucine rich repeat region which ... -
Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future
O'Neill, Luke (2022)A plethora of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic tests are available, each with different performance specifications, detection methods, and targets. This narrative review aims to ... -
A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.
Keane, Joseph; O'Sullivan, Mary; O'Neill, Luke; Lavelle, Edward; Corr, Sinead; Palsson Mcdermott, Eva; Sheedy, Frederick; Ni Cheallaigh, Cliona; Gleeson, Laura; Munoz-Wolf, Natalia (2016)Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those ... -
Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14.
O'Neill, Luke; Doyle, Sarah; Canavan, Mary (2013)Polyunsaturated fatty acids (PUFA) can modulate the immune response, however the mechanism by which they exert this effect remains unclear. Previous studies have clearly demonstrated that the cis-9, trans-11 isomer of ... -
Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication.
Keane, Joseph; O'Sullivan, Mary; O'Neill, Luke; Palsson Mcdermott, Eva; Sheedy, Frederick; Gleeson, Laura (2016)Recent advances in immunometabolism link metabolic changes in stimulated macrophages to production of IL-1β, a crucial cytokine in the innate immune response to Mycobacterium tuberculosis. To investigate this pathway in ... -
Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production
O'Neill, Luke (2019)Innate immune responses vary in a circadian manner, and more recent investigations aim to understand the underlying molecular mechanisms. Cytokine production varies significantly over the course of a day depending on the ... -
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
O'Neill, Luke; Baardman, Jeroen; Verberk, Sanne G.S.; Prange, Koen H.M.; van Weeghel, Michel; van der Velden, Saskia; Ryan, Dylan G.; Wüst, Rob C.I.; Neele, Annette; Speijer, Dave; Denis, Simone W.; Witte, Maarten E.; Houtkooper, Riekelt H.; Knatko, Elena V.; Dinkova-Kostova, Albena T.; Lutgens, Esther; de Winther, Menno P.J.; Van den Bossche, Jan (2018)Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of ... -
Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis
Phelan, James; Keane, Joseph; Basdeo, Sharee; O'Sullivan, Mary; O'Neill, Luke (2020)Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis ...