Browsing by Author "O'BRIEN, FERGAL"
Now showing items 1-20 of 27
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Biomaterial based modulation of macrophage polarization: A review and suggested design principles
KELLY, DANIEL; O'BRIEN, FERGAL (2015)Macrophages have long been known for their phagocytic capabilities and immune defence; however, their role in healing is being increasingly recognized in recent years due to their ability to polarize into pro-inflammatory ... -
A biomimetic multi-layered collagen-based scaffold for osteochondral repair
O'BRIEN, FERGAL (2014)Cartilage and osteochondral defects pose a significant challenge in orthopedics. Tissue engineering has shown promise as a potential method for the treatment of such defects; however, a long-lasting repair strategy has yet ... -
A collagen hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates
O'BRIEN, FERGAL (2014)An emerging paradigm in orthopedics is that a bone-healing outcome is the product of the anabolic (bone-forming) and catabolic (bone-resorbing) outcomes. Recently, surgical and tissue engineering strat- egies have emerged ... -
Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart.
O'BRIEN, FERGAL (2014)Cell delivery to the infarcted heart has emerged as a promising therapy, but is limited by very low acute retention and engraftment of cells. The objective of this study was to compare a panel of biomaterials to evaluate ... -
Crosslinking and mechanical properties significantly influence cell attachment, proliferation, and migration within collagen glycosaminoglycan scaffolds.
O'BRIEN, FERGAL (2011)Crosslinking and the resultant changes in mechanical properties have been shown to influence cellular activity within collagen biomaterials. With this in mind, we sought to determine the effects of crosslinking on both the ... -
The Development of Non-Viral Gene-Activated Matrices for Bone Regeneration Using Polyethyleneimine (PEI) and Collagen-Based Scaffolds
O'BRIEN, FERGAL; DUFFY, GARRY (2012)The healing potential of scaffolds for tissue engineering can be enhanced by combining them with genes to produce gene-activated matrices (GAMs) for tissue regeneration. We examined the potential of using polyethyleneimine ... -
The effect of bisphosphonate treatment on the biochemical and cellular events during bone remodelling in response to microinjury stimulation
TAYLOR, DAVID; O'BRIEN, FERGAL (2015)Osteoporosis is one of the most prevalent bone diseases worldwide and is characterised by high levels of bone turnover, a marked loss in bone mass and accumulation of microdamage, which leads ... -
Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration
KELLY, DANIEL; BUCKLEY, CONOR; O'BRIEN, FERGAL; CUNNIFFE, GRÁINNE (2016) -
In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells
O'BRIEN, FERGAL (2011)Background: Bone grafts are required to repair large bone defects after tumour resection or large trauma. The availability of patients?U? own bone tissue that can be used for these procedures is limited. Thus far bone ... -
Infrapatellar Fat Pad Stem Cells: From Developmental Biology to Cell Therapy
KELLY, DANIEL; O'BRIEN, FERGAL (2017) -
Innovations in gene and growth factor delivery systems for diabetic wound healing
O'BRIEN, FERGAL; Laiva, Ashang Luwang; Keogh, Michael B. (2017)The rise in lower extremity amputations due to nonhealing of foot ulcers in diabetic patients calls for rapid improvement in effective treatment regimens. Administration of growth factors (GFs) are thought to offer an ... -
Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector
KELLY, DANIEL; NICOLOSI, VALERIA; CUNNIFFE, GR?INNE; O'BRIEN, FERGAL (2017) -
Mesenchymal stem cell fate is regulated by the composition and mechanical properties of Collagen Glycosaminoglycan scaffolds
O'BRIEN, FERGAL (Elsevier, 2012)In stem cell biology, focus has recently turned to the influence of the intrinsic properties of the extracellular matrix (ECM), such as structural, composition and elasticity, on stem cell differentiation. Utilising ... -
Part 1: scaffolds and surfaces.
O'BRIEN, FERGAL (Elsevier, 2008)Every day thousands of clinical procedures are performed to replace or repair tissues in the human body that have been damaged through disease or trauma. Current therapies are focused on the replacement of the damaged ... -
Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing
KELLY, DANIEL; VINARDELL, TATIANA; CUNNIFFE, GR?INNE; O'BRIEN, FERGAL (2015)Clinical translation of tissue engineered therapeutics is hampered by the significant logistical and regulatory challenges associated with such products, prompting increased interest in the use of decellularized extracellular ... -
Porous Scaffolds Derived from Devitalized Tissue Engineered Cartilaginous Matrix Support Chondrogenesis of Adult Stem Cells
KELLY, DANIEL; O'BRIEN, FERGAL (2017)