Browsing by Author "Nulty, Ciara"
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Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis
Creagh, Emma; Mills, Kingston; Flood, Brie; Manils, Joan; Nulty, Ciara; Flis, Ewelina; Kenealy, Sinead; Barber, Gillian; Fay, Joanna; Kay, Elaine (2019)Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for the ... -
Understanding the mechanism and functional effects of caspase-11 regulated nitric oxide production during inflammation and cancer
Nulty, Ciara (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Inflammatory caspases are a group of cysteine aspartic proteinases essential for the inflammatory process, but when dysregulated are implicated in inflammatory diseases and cancer-associated chronic inflammatory events. ...