Browsing by Author "Mitchell, Kevin"
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Building a supportive framework for brain research in Ireland: Inaugural position paper of the Irish Brain Council
Hardiman, Orla; Mitchell, Kevin; Pender, Niall (Wiley, 2019)The Irish Brain Council is an independent group of organisations which have come together to influence and impact upon brain research in Ireland. The purpose of the Irish Brain Council is to promote ... -
Data for 3D reconstruction of the corticospinal tract in the wild-type and Semaphorin 6A knockout adult brain
Mitchell, Kevin (2019)The corticospinal tract (CST) has a complex and long trajectory throughout the brain. Semaphorin 6A (Sema6A), a member of the semaphorin family, is one of the important regulators of CST axon guidance. Previous studies ... -
Disrupted in schizophrenia 1 (DISC1) mutants have impaired activity-dependent plasticity in vitro and in vivo
Corvin, Aiden; Mitchell, Kevin (2016) -
Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age
Cunningham, Colm; Mitchell, Kevin (2021)Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C is frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative disorders ... -
A dual-strategy expression screen for candidate connectivity labels in the developing thalamus
Hokamp, Karsten; Mitchell, Kevin (2017) -
Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1
Mitchell, Kevin (2017)Few studies have addressed likely gene × gene (ie, epistatic) interactions in mediating risk for schizophrenia. Using a preclinical genetic approach, we investigated whether simultaneous disruption of the risk factors ... -
Insufficient Evidence for "Autism-Specific" Genes
Mitchell, Kevin; Challman, Thomas D.; Bernier, Raphael; Bourgeron, Thomas; Chung, Wendy K.; Constantino, John N.; Eichler, Evan E.; Jacquemont, Sebastien; Miller, David T.; Zoghbi, Huda Y.; Martin, Christa Lese; Ledbetter, David H. (2020)Despite evidence that deleterious variants in the same genes are implicated across multiple neurodevelopmental and neuropsychiatric disorders, there has been considerable interest in identifying genes that, when mutated, ... -
Neurogenomics - towards a more rigorous science
Mitchell, Kevin (2018)The field of neurogenomics is coming of age, but not without some teething problems. The aim of this field is to understand the genetic basis of differences in brain structure and function, which in turn underlie differences ... -
Remarkable complexity and variability of corticospinal tract defects in adult Semaphorin 6A knockout mice
Mitchell, Kevin (2019)The corticospinal tract (CST) has a complex and long trajectory that originates in the cerebral cortex and ends in the spinal cord. Semaphorin 6A (Sema6A), a member of the semaphorin family, is an important regulator of ... -
The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia
Mitchell, Kevin (2019)A recent development in the genetic architecture of schizophrenia suggested that an omnigenic model may underlie the risk for this disorder. The aim of our study was to use polygenic profile scoring to quantitatively assess ... -
Synaesthesia lost and found: two cases of person- and music-colour synaesthesia
Mitchell, Kevin (2017)Synaesthesia is a developmental condition involving cross-communication between sensory modalities or substreams whereby an inducer (e.g. a sound) automatically evokes a concurrent percept in another modality (e.g. a ...