Browsing by Author "Mills, Kingston"
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Activation and function of mucosal gamma delta T cells
Misiak, Alicja (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)γδ T cells are innate-like lymphocytes characterised by rapid activation following infection or tissue injury. They are enriched in the skin and epitheliae of various organs, where breach of the barrier is likely to occur. ... -
Activation of innate immunity by Bordetella pertussis
Higgins, Sarah (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)Respiratory infection with Bordetella pertussis is associated with the induction of Th1 cells and these cells, as well as antibody and cells of the innate immune system mediate the clearance of bacteria from the lungs. ... -
Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus
Lynch, Marina; Kelly, Aine; Mills, Kingston (2003)Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria, has been shown to induce profound changes both peripherally and centrally. It has recently been reported that intraperitoneal injection of ... -
Author Correction: A guiding map for inflammation (Nature Immunology, (2017), 18, 8, (826-831), 10.1038/ni.3790)
Mills, Kingston; O'Neill, Luke (2021) -
Bystander activation of Bordetella pertussis-induced nasal tissue-resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniae
Mills, Kingston (2023)Tissue-resident memory CD4 T (TRM) cells induced by infection with Bordetella pertussis persist in respiratory tissues and confer long-term protective immunity against reinfection. However, it is not clear how they are ... -
Caspase-11 promotes allergic airway inflammation
Creagh, Emma; Lavelle, Edward; O'Neill, Luke; Mills, Kingston; Zasłona, Zbigniew; Flis, Ewelina; Wilk, Mieszko M.; Carroll, Richard G.; Palsson-McDermott, Eva M.; Hughes, Mark M.; Diskin, Ciana; Banahan, Kathy; Ryan, Dylan G.; Hooftman, Alexander; Misiak, Alicja; Kearney, Jay; Lochnit, Gunter; Bertrams, Wilhelm; Greulich, Timm; Schmeck, Bernd; McElvaney, Oliver J.; Wygrecka, Małgorzata (2020)Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 ... -
Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis
Creagh, Emma; Mills, Kingston; Flood, Brie; Manils, Joan; Nulty, Ciara; Flis, Ewelina; Kenealy, Sinead; Barber, Gillian; Fay, Joanna; Kay, Elaine (2019)Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for the ... -
CD4 TRMcells following infection and immunization: Implications for more effective vaccine design
Mills, Kingston; Wilk, Mieszko M. (2018)The induction of immunological memory, which is mediated by memory T and B cells, is central to adaptive protective immunity to pathogens induced by previous infection and is the cornerstone of effective vaccine design. ... -
The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing
Mills, Kingston; Finlay, David (2022)Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. Circadian rhythms are known to regulate many aspects of immunity; however, the role of circadian rhythms ... -
Correction: IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils
Mills, Kingston (2021)The original version of this article unfortunately contained a mistake in Fig. 3h. Due to a typesetting error the lines on the graph have been moved below the X axis. We apologize for this error. The correct Fig. 3h can ... -
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Mills, Kingston; Carty, Michael; Ni Cheallaigh, Cliona (2023)Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one of the leading ... -
The Effects of Trained Innate Immunity on T Cell Responses; Clinical Implications and Knowledge Gaps for Future Research
Mills, Kingston; Basdeo, Sharee (2021)The burgeoning field of innate immune training, also called trained immunity, has given immunologists new insights into the role of innate responses in protection against infection and in modulating inflammation. Moreover, ... -
Factors influencing the induction of immune responses with DNA vaccines
Daly, Lyn M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)Compared with any other medical discovery vaccines have prevented more deaths and suffering. Emergence of novel pathogens accentuates the requisite for ongoing development and improvement of traditional vaccination strategies. ... -
The function and regulation of IL-17A-producing T cell subsets in central nervous system autoimmunity
Leane, Charlotte Maryse (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Multiple sclerosis (MS) is a chronic progressive autoimmune disease of the central nervous system (CNS). MS is characterised by the presence of demyelinating lesions in the CNS and is the leading cause of disability among ... -
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
Mills, Kingston; Corr, Sinead; Palsson Mcdermott, Eva; Mc Gettrick-Dillon, Anne (2019)NLRP3 inflammasome activation contributes to chronic inflammationassociated with autoinflammatorydisease, yet understanding of NLRP3inflammasome regulation is incomplete.Hughes et al. show that thedeglutathionylating enzyme ... -
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Mills, Kingston; Cossarizza, Andrea; Chang, Hyun-Dong; Radbruch, Andreas; Acs, Andreas; Adam, Dieter; Adam-Klages, Sabine; Agace, William W.; Aghaeepour, Nima; Akdis, Mübeccel; Allez, Matthieu; Nogueira Almeida, Larissa; Alvisi, Giorgia; Anderson, Graham; Andrä, Immanuel; Annunziato, Francesco; Anselmo, Achille; Bacher, Petra; Baldari, Cosima T.; Bari, Sudipto; Barnaba, Vincenzo; Barros-Martins, Joana; Battistini, Luca; Bauer, Wolfgang; Baumgart, Sabine; Baumgarth, Nicole; Baumjohann, Dirk; Baying, Bianka; Bebawy, Mary; Becher, Burkhard (2019)These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid ... -
Helminth products promote anti-inflammatory trained innate immunity by imprinting long-term hematopoietic stem cells
Cunningham, Kyle (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Recent research has shown that immunological memory is not confined to the cells of the adaptive immune system but can be imbued upon innate immune cells, including monocytes and macrophages, in a process known as trained ... -
IL-17 and IL-17-producing cells in protection versus pathology
Mills, Kingston (2023)IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology during infection and autoimmunity. IL-17A and IL-17F are produced ... -
IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F + neutrophils
Moran, Barry; Mills, Kingston (2021)Understanding the mechanism of protective immunity in the nasal mucosae is central to the design of more effective vaccines that prevent nasal infection and transmission of Bordetella pertussis. We found significant ...