Browsing by Author "Mc Gettrick-Dillon, Anne"
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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
Mills, Kingston; Corr, Sinead; Palsson Mcdermott, Eva; Mc Gettrick-Dillon, Anne (2019)NLRP3 inflammasome activation contributes to chronic inflammationassociated with autoinflammatorydisease, yet understanding of NLRP3inflammasome regulation is incomplete.Hughes et al. show that thedeglutathionylating enzyme ... -
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
Mc Gettrick-Dillon, Anne; O'Neill, Luke (Springer Nature, 2023-03-08)Metabolic rewiring underlies the effector functions of macrophages, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory ...