Browsing by Author "MURPHY, PAULA"
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Determination, diversification and multipotency of mammalian myogenic cells
MURPHY, PAULA (2008)In amniotes, myogenic commitment appears to be dependent upon signaling from neural tube and dorsal ectoderm, that can be replaced by members of the Wnt family and by Sonic hedgehog. Once committed, myoblasts undergo ... -
Dynamic pattern of mechanical stimulation promotes ossification in avian embryonic long bones
MURPHY, PAULA; NOWLAN, NIAMH CATHERINE; Prendergast, Patrick John (Elsevier, 2007) -
Effects of retinoic acid excess on expression oh Hox 2.9 and Krox 20 and on morphological segmentation in the hindbrain of mouse embryos
MURPHY, PAULA (Nature Publishing Group, 1991)Mouse embryos were exposed to maternally administered RA on day 8.0 or day 7 3/4 of development, i.e. at or just before the differentiation of the cranial neural plate, and before the start of segmentation. On day 9.0, the ... -
Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segementation of the hindbrain
MURPHY, PAULA (Company of Biologists, 1991)The sequence of a mouse Hox 2.9 cDNA clone is presented. The predicted homeodomain is similar to that of the Drosophila gene labial showing 80 % identity. The equivalent gene in the Hox 1 cluster is Hox 1.6 which shows ... -
Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription
MURPHY, PAULA (1998)We have previously shown that the widely expressed human transcription factor TCF11/LCR-F1/Nrf1 interacts with small Maf proteins and binds to a subclass of AP1-sites. Such sites are required for b-globin 54 DNase I ... -
Mechanobiology of embryonic limb development
Prendergast, Patrick; NOWLAN, NIAMH CATHERINE; MURPHY, PAULA (2007)Considerable evidence exists to support the hypothesis that mechanical forces have an essential role in healthy embryonic skeletal development. Clinical observations and experimental data indicate the importance of muscle ... -
Plxdc2 is a mitogen for neural progenitors
MURPHY, PAULA; MITCHELL, KEVIN (2011)The development of different brain regions involves the coordinated control of proliferation and cell fate specification along and across the neuraxis. Here, we identify Plxdc2 as a novel regulator of these processes, using ... -
The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development.
MURPHY, PAULA (Company of Biologists, 1996)The zinc finger transcription factor gene Krox-20 is expressed in Schwann cells and is required for the myelination of peripheral nerves. We show that the regulation of Krox-20 expression in peripheral glial cells reveals ... -
Two domains of the human bZIP transcription factor TCF11 are necessary for transactivation
MURPHY, PAULA (American Society for Biochemistry and Molecular Biology, 2001) -
The Wnt/?-catenin pathway regulates the Shh-mediated Myf5
MURPHY, PAULA (2006)