Browsing by Author "MITCHELL, KEVIN"
Now showing items 1-20 of 21
- Sort by:
- title
- issue date
- submit date
- Order:
- ascending
- descending
- Results:
- 5
- 10
- 20
- 40
- 60
- 80
- 100
-
Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism
MITCHELL, KEVIN; LITTLE, GRAHAM (2007)Background: In developing neurons, somal migration and initiation of axon outgrowth often occur simultaneously and are regulated in part by similar classes of molecules. When neurons reach their final destinations, however, ... -
Combined structural and functional imaging reveals cortical deactivations in grapheme-color synaesthesia.
NEWELL, FIONA; MITCHELL, KEVIN (2013) -
Expression of Plxdc2/TEM7R in the developing nervous system of the mouse.
MITCHELL, KEVIN (2007)Plexin-domain containing 2 (Plxdc2) is a relatively uncharacterised transmembrane protein with an area of nidogen homology and a plexin repeat (PSI domain) in its extracellular region. Here, we describe Plxdc2 expression ... -
The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns.
MITCHELL, KEVIN; DOLAN, JACKIE; HOKAMP, KARSTEN; OKAFUJI, TATSUYA (2007)BACKGROUND: Leucine-rich repeats (LRRs) are highly versatile and evolvable protein-ligand interaction motifs found in a large number of proteins with diverse functions, including innate immunity and nervous system development. ... -
Following the genes: a framework for animal modeling of psychiatric disorders.
MITCHELL, KEVIN (2011)The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models ... -
Genetic entropy and the human intellect
MITCHELL, KEVIN (2013) -
The genetics of brain wiring: from molecule to mind.
MITCHELL, KEVIN (2007)What makes some people neurotic or schizophrenic or right-handed or fearless? Are these behavioural differences caused by literal differences in how individuals' brains are wired? If so, what causes those differences? This ... -
The genetics of neurodevelopmental disease
MITCHELL, KEVIN (Elsevier, 2011)The term neurodevelopmental disorder encompasses a wide range of diseases, including recognizably distinct syndromes known to be caused by very rare mutations in specific genes or chromosomal loci, and also much more common ... -
The miswired brain: making connections from neurodevelopment to psychopathology
MITCHELL, KEVIN (BIOMED CENTRAL, 2011)Developmental neurobiologists have made great progress in elucidating the molecular mechanisms underlying nervous system development. There has been less focus, however, on the consequences when these processes go wrong. ... -
Mutation of Semaphorin-6A Disrupts Limbic and Cortical Connectivity and Models Neurodevelopmental Psychpathology
GILL, MICHAEL; CORVIN, AIDEN; MITCHELL, KEVIN (2011) -
Mutation of Elfn1 in Mice Causes Seizures and Hyperactivity
MITCHELL, KEVIN (2013) -
Mutation of Semaphorin-6A Disrupts Limbic and Cortical Connectivity and Models Neurodevelopmental Psychopathology
GILL, MICHAEL; MORRIS, DEREK; CORVIN, AIDEN; MITCHELL, KEVIN (2011)Psychiatric disorders such as schizophrenia and autism are characterised by cellular disorganisation and dysconnectivity across the brain and can be caused by mutations in genes that control neurodevelopmental processes. ... -
Plxdc2 is a mitogen for neural progenitors
MURPHY, PAULA; MITCHELL, KEVIN (2011)The development of different brain regions involves the coordinated control of proliferation and cell fate specification along and across the neuraxis. Here, we identify Plxdc2 as a novel regulator of these processes, using ... -
Rethinking the genetic architecture of schizophrenia
MITCHELL, KEVIN (Cambridge University Press, 2011)Background. For many years, the prevailing paradigm has stated that in each individual with schizophrenia (SZ) the genetic risk is due to a combination of many genetic variants, individually of small effect. Recent empirical ... -
Reverse signaling by semaphorin-6A regulates cellular aggregation and neuronal morphology
MITCHELL, KEVIN (2016)The transmembrane semaphorin, Sema6A, has important roles in axon guidance, cell migration and neuronal connectivity in multiple regions of the nervous system, mediated by context-dependent interactions with plexin receptors, ... -
Roles of Semaphorin-6B and Plexin-A2 in Lamina-Restricted Projection of Hippocampal Mossy Fibers.
MITCHELL, KEVIN (2010)Hippocampal mossy fibers project preferentially to the proximal-most lamina of the suprapyramidal region of CA3, the stratum lucidum, and proximal-most parts of the infrapyrmidal region of CA3c. Molecular mechanisms that ... -
Roles of Semaphorin-6B and Plexin-A2 in Lamina-Restricted Projection of Hippocampal Mossy Fibers.
MITCHELL, KEVIN (Society for Neuroscience, 2010)Hippocampal mossy fibers project preferentially to the proximal-most lamina of the suprapyramidal region of CA3, the stratum lucidum, and proximal-most parts of the infrapyrmidal region of CA3c. Molecular mechanisms that ... -
Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.
MITCHELL, KEVIN; LITTLE, GRAHAM (2008)Background: The trajectory of corticospinal tract (CST) axons from cortex to spinal cord involves a succession of choice points, each of which is controlled by multiple guidance molecules. To assess the involvement of ... -
Specificity and plasticity of thalamocortical connections in Sema6A mutant mice.
MITCHELL, KEVIN; LITTLE, GRAHAM (2009)The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate ...