Browsing by Author "MILLS, KINGSTON"
Now showing items 1-20 of 89
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Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential.
MILLS, KINGSTON; CREAGH, EMMA (2015)Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis. Altered activity of caspases, particularly caspase-1, has ... -
Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells
MILLS, KINGSTON; KEANE, JOSEPH; RUANE, DARREN; COLEMAN, MICHELLE; MORAN, BARRY (2013)Alveolar macrophages (AMs) from mice and humans have long been known to contribute to maintaining tolerance in the lung. Studies have shown that AMs can induce anergy in CD4+ T cells. Nitric oxide, prostaglandins, and ... -
Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions in IFN- ? receptor or immunoglobulin Y chain genes
MILLS, KINGSTON (The Rockefeller University Press, 1997)Using a murine respiratory challenge model we have previously demonstrated a role for Th1 cells in natural immunity against Bordetella pertussis, but could not rule out a role for antibody. Here we have demonstrated that ... -
Autophagy and inflammatory diseases.
MILLS, KINGSTON (2013)Autophagy is a cellular mechanism for the sequestration and degradation of intracellular pathogens and compromised organelles, particularly damaged mitochondria. Autophagy also clears other cellular components, such as ... -
Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells
GALVIN, KAREN; HIGGINS, SARAH; MILLS, KINGSTON; STEFANSKA, ANNA; MORAN, BARRY; DUNGAN, LARA (2013)The immune system has evolved regulatory mechanisms to control immune responses to self-antigens. Regulatory T (Treg) cells play a pivotal role in maintaining immune tolerance, but tumour growth is associated with local ... -
Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.
MILLS, KINGSTON (2014)Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and delivers into their cytosol an adenylyl cyclase (AC) enzyme that ... -
Cell mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model
MILLS, KINGSTON (American Society for Microbiology, 1993)A murine respiratory infection model was used to study the mechanism of protective immunity to Bordetella pertussis. We found that nude mice, which are deficient in T cells, developed a persistent infection and failed to ...