Browsing by Author "MEDINA MARTIN, CARLOS"
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Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells inflammatory and cytotoxicity effects.
RADOMSKI, MAREK; MEDINA MARTIN, CARLOS (2011)BACKGROUND: The purpose of this study was to investigate the mechanism of noxious effects of amorphous silica nanoparticles on human endothelial cells. METHODS: Nanoparticle uptake was examined by transmission electron ... -
Amorphus Silica Nanopartilces Aggregate Human Platelets: Potential Implications for Vascular Haemostasis.
MEDINA MARTIN, CARLOS (2012) -
Analysis of platelet function: role of microfluidics and nanodevices
RADOMSKI, MAREK; MEDINA MARTIN, CARLOS; SANTOS-MARTINEZ, MARIA (2011)Platelet aggregation is essential for vascular haemostasis and thrombosis. To improve the therapy of arterial thrombotic disorders and identify novel therapeutic targets it is imperative to study basic mechanisms of platelet ... -
CdTe quantum dots induce activation of human platelets: Implications for nanoparticle hemocompatibility
PRINA MELLO, ADRIELE; SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS; VOLKOV, YURI (2015) -
Chondroitin-based nanoplexes as peptide delivery systems--Investigations into the self-assembly process, solid-state and extended release characteristics.
TAJBER, LIDIA; SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS (2015) -
Cytoskeletal re-arrangement in TGF-beta1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis
EHRHARDT, CARSTEN; DAVIES, ANTHONY; MEDINA MARTIN, CARLOS (2012)Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis of idiopathic pulmonary fibrosis. Associated with this phenotypic transition is acquisition of an elongated cell morphology and establishment ... -
Differential Inhibition of Tumor Cell-Induced Platelet Aggregation by Nicotinate Aspirin Prodrug (ST0702) and Aspirin.
SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS (2012) -
Elucidation of Flow Mediated TCIPA Using an Ultrasound Standing Wave Trap
MEDINA MARTIN, CARLOS (2011) -
Exploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers
TAJBER, LIDIA; SANTOS-MARTINEZ, MARIA; CORRIGAN, OWEN; UMERSKA, ANITA MONIKA; PALUCH, KRZYSZTOF; MEDINA MARTIN, CARLOS (2012) -
In Vitro Pharmacology of Aspirin Prodrugs in Human Platelets
MEDINA MARTIN, CARLOS (2012) -
Interplay between the receptor for advanced glycation end-products (RAGE), CD44 and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells
EHRHARDT, CARSTEN; MEDINA MARTIN, CARLOS; BUCKLEY, STEPHEN (2011) -
Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis.
RADOMSKI, MAREK; MEDINA MARTIN, CARLOS (2006)Proteolysis and degradation of extracellular matrix by metalloproteinases (MMPs) may contribute to intestinal injury in inflammatory bowel disease. In the present study, we investigated the pathogenic role of gelatinases ... -
Matrix metalloproteinases in inflammatory bowel disease: an update
GILMER, JOHN; MEDINA MARTIN, CARLOS (2015)Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. ... -
Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway.
SANTOS-MARTINEZ, MARIA; RADOMSKI, MAREK; MEDINA MARTIN, CARLOS (2014) -
MMP inhibition by barbiturate homodimers
RADOMSKI, MAREK; MEDINA MARTIN, CARLOS (2013)We have studied some homodimeric compounds derived from 5-homopiperazine substituted pyrimidine triones (barbiturates) with linkers in the range 2-20 carbon atoms. The compounds were designed to be capable of resisting ... -
N-subsituted homopiperazine barbiturates as gelatinase inhibitors
RADOMSKI, MAREK; WANG, JUN; MEDINA MARTIN, CARLOS; GILMER, JOHN (2011)Matrix metalloproteinases are implicated in a wide range of pathophysiological processes and potent selective inhibitors for these enzymes continue to be eagerly sought. 5,5-Disubstituted barbiturates hold promise as ... -
Nanoparticles: pharmacological and toxicological significance
RADOMSKI, MAREK; SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS; CORRIGAN, OWEN (2007) -
Nitric oxide-matrix metaloproteinase-9 interactions: Biological and pharmacological significance: NO and MMP-9 interactions
RADOMSKI, MAREK; MEDINA MARTIN, CARLOS (2014) -
Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride
MEDINA MARTIN, CARLOS; RADOMSKI, MAREK (2014) -
Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry
RADOMSKI, MAREK; SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS (2015)