Browsing by Author "MC CABE, THOMAS"
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Asymmetric acyl-transfer promoted by readily assembled chiral 4-N,N-dialkylaminopyridine derivatives CONNON, STEPHEN; MC CABE, THOMAS; WATSON, GRAEME WILLIAM (Royal Society of Chemistry, 2006)The development of a new class of chiral 4-N,N-dialkylaminopyridine acyl-transfer catalysts capable of exploiting both van der Waals (?) and H-bonding interactions to allow remote chiral information to stereochemically ...
Hydrogen bonding interactions and supramolecular networks of pyridine-aryl based thiosemicarbazides and their Zn(II) complexes GUNNLAUGSSON, THORFINNUR; PANDURANGAN, KOMALA; MC CABE, THOMAS; KITCHEN, JOANNE (2013)The synthesis of five pyridyl derived thiosemicarbazides, 1-5, is presented. All five were formed in a single step from 2-hydrazinopyridine with commercially available isothiocyanates using microwave assisted synthesis. ...
Preliminary investigations on novel camphor-derived chiral sulfones: completely stereoselective formation of tricyclic ?-hydroxysulfones from 8- and 10- functionalized camphor derivatives MC CABE, THOMAS; GRAYSON, DAVID (Elsevier, 2011)Some camphor-derived chiral allylic and benzylic sulfones in which the sulfonyl group is located at the C-10, C-9 or C-8 methyl groups of (+)-camphor were synthesized. The C-9 and C-8 substituted sulfones were obtained via ...
Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: intermolecular self assembly suprastructures O'BRIEN, JOHN EUGENE; HEALY, ANNE MARIE; TAJBER, LIDIA; CORRIGAN, OWEN; MC CABE, THOMAS; PALUCH, KRZYSZTOF (Elsevier, 2011)Chlorothiazide (CTZ) is a poorly soluble diuretic agent. The aim of the present work was to produce and characterise a potassium salt form of chlorothiazide which has the potential advantages of improved aqueous solubility ...
Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure TAJBER, LIDIA; MC CABE, THOMAS; HEALY, ANNE MARIE; O'BRIEN, JOHN EUGENE; CORRIGAN, OWEN; PALUCH, KRZYSZTOF (Elsevier, 2010)Chlorothiazide (CTZ), unlike other thiazide diuretics, can form salts. An injectable formulation containing the sodium salt is available; however neither the physicochemical characteristics of the salt nor its solid state ...
Synthesis, Biochemical and Molecular Modelling Studies of Antiproliferative Azetidinones causing Microtubule Disruption and Mitotic Catastrophe MEEGAN, MARY JANE; ZISTERER, DANIELA MARIA; KEELY, NIALL O.; MC CABE, THOMAS; GREENE, LISA; KNOX, ANDREW; LLOYD, DAVID G; O'BOYLE, NIAMH (Elsevier, 2011)The structure-activity relationships of antiproliferative ?-lactams, focusing on modifications at the 4-position of the ?-lactam ring, is described. Synthesis of this series of compounds was achieved utilizing the Staudinger ...