Browsing by Author "LYNCH, MARINA ANNETTA"
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α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
LYNCH, MARINA; LYNCH, MARINA ANNETTA (2015)The immunoregulatory function of single-Ig-interleukin-1 related receptor (SIGIRR) is derived from its ability to constrain the inflammatory consequences of interleukin (IL)-1R and toll-like receptor (TLR)4 activation. ... -
Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL
LYNCH, MARINA ANNETTA (2012)Altered synaptic morphology, progressive loss of synapses and glial (astrocyte and microglial) cell activation are considered as characteristic hallmarks of ageing. Recent evidence suggests that there is a concomitant ... -
The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon.
LYNCH, MARINA ANNETTA (2013)A non-selective antihistamine, dimebon, has recently emerged as a potential treatment for Alzheimer's disease and Huntington's disease. Dimebon exerts several effects in addition to its anti-histaminergic effect, and of ... -
Age-related neuroinflammatory changes negatively impact on neuronal function.
LYNCH, MARINA ANNETTA (2010)Neuroinflammatory changes, characterized by an increase in microglial activation and often accompanied by upregulation of inflammatory cytokines like interleukin-1? (IL-1?), are common to many, if not all, neurodegenerative ... -
Amyloid-beta-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE.
LYNCH, MARINA ANNETTA; MINOGUE, AEDIN (2013) -
Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli.
LYNCH, MARINA; MINOGUE, AEDIN; MINOGUE, AEDIN; LYNCH, MARINA ANNETTA (2015)Macrophages are key cells in tissue defense in the periphery and, under certain circumstances, infiltrate the central nervous system, where they may play a similar role in the brain, perhaps supporting the function of ... -
CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4.
LYNCH, MARINA ANNETTA; MILLS, KINGSTON (Society for Neuroscience, 2007)Deficits in cognitive function are associated with neuroinflammatory changes, typified by activation of glial cells and an alteration of the pro- and anti-inflammatory cytokine balance in the brain. Although there is ... -
Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells.
LYNCH, MARINA ANNETTA (2013)The interaction between CD200, expressed on several cell types, and its receptor CD200R, expressed on cells of the myeloid lineage, has been shown to be an important factor in modulating inflammation in macrophage function ... -
The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation.
LYNCH, MARINA ANNETTA; MURPHY, NIAMH; GOWRAN, AOIFE; CAMPBELL, VERONICA ANN (2012)Background: Several factors contribute to the deterioration in synaptic plasticity which accompanies age and one of these is neuroinflammation. This is characterized by increased microglial activation associated with ... -
Glial Activation in A?PP/PS1 Mice is Associated with Infiltration of IFN?-Producing Cells.
LYNCH, MARINA ANNETTA; COSTELLO, DEREK; MINOGUE, AEDIN (2013) -
How dependent is synaptic plasticity on microglial phenotype?
LYNCH, MARINA; LYNCH, MARINA ANNETTA (2015)Microglia are particularly plastic cells which can be shifted from their resting state by numerous factors and adopt distinct phenotypes. The cells are multifunctional, though their main role is probably maintenance of ... -
IFN-? Production by Amyloid ?-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease.
MILLS, KINGSTON; LYNCH, MARINA ANNETTA (2013)Alzheimer?s disease (AD) is characterized by the presence of amyloid-b (Ab)?containing plaques, neurofibrillary tangles, and neuronal loss in the brain. Inflammatory changes, typified by activated microglia, particularly ... -
IL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice
LYNCH, MARINA ANNETTA; COSTELLO, DEREK (2011)Single-Ig-interleukin-1 related receptor (SIGIRR) is a member of the interleukin (IL)-1/Toll-like receptor (TLR) family. It negatively regulates inflammation, rendering SIGIRR-/- mice more susceptible to inflammatory ... -
Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased A? accumulation and microglial activation.
LYNCH, MARINA ANNETTA; MINOGUE, AEDIN (2013)Background: Alzheimer?s Disease is characterized by progressive neuronal loss and cognitive decline. Epidemiological studies suggest that the risk of AD is higher in women even when data are adjusted for age. Objective: ... -
Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction.
LYNCH, MARINA ANNETTA (2013)Increasing global birth rate, coupled with the aging population surviving into their eighth decade has lead 26 to increased incidence diseases, hitherto designated as rare. Brain related ischemia, at birth, or later in ... -
LPS-induced release of IL-6 from glia modulates production of IL-1? in a JAK2-dependent manner.
MINOGUE, AEDIN; BARRETT, JAMES; LYNCH, MARINA ANNETTA (2012)Background: Compelling evidence has implicated neuroinflammation in the pathogenesis of a number of neurodegenerative conditions. Chronic activation of both astrocytes and microglia leads to excessive secretion ... -
Modest Amyloid Deposition is Associated with Iron Dysregulation, Microglial Activation, and Oxidative Stress.
LYNCH, MARINA ANNETTA (2012)There is a well-established literature indicating a relationship between iron in brain tissue and Alzheimer's disease (AD). More recently, it has become clear that AD is associated with neuroinflammatory and oxidative ... -
A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus
LYNCH, MARINA ANNETTA; COWLEY, THELMA (Elsevier, 2011)Neuroglial activation is a typical hallmark of ageing within the hippocampus, and correlates with age-related cognitive deficits. We have used quantitative immunohistochemistry and morphometric analyses to investigate ... -
The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner.
LYNCH, MARINA ANNETTA (2013)Fibroblast growth loop (FGL) is a neural cell adhesion molecule (NCAM)-mimetic peptide that mimics the interaction of NCAM with fibroblast growth factor receptor (FGFR). FGL increases neurite outgrowth and promotes ... -
Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β
LYNCH, MARINA; LYNCH, MARINA ANNETTA (2015)In recent years it has become clear that neuroinflammatory changes develop in the brain with age and that similar, though more profound changes, occur in neurodegenerative conditions and in animal models of neurodegeneration. ...