Browsing by Author "LONG, AIDEEN"
Now showing items 1-17 of 17
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Advances in siRNA delivery to T-cells: potential clinical applications for inflammatory disease, cancer and infection.
FREELEY, MICHAEL; LONG, AIDEEN (2013)The specificity of RNAi and its ability to silence 'undruggable' targets has made inhibition of gene expression in T-cells with siRNAs an attractive potential therapeutic strategy for the treatment of inflammatory disease, ... -
Deoxycholic acid promotes development of gastroesophageal reflux disease and Barrett's oesophagus by modulating integrin-??v trafficking
FINN, STEPHEN; O'SULLIVAN, JACINTHA; LONG, AIDEEN; BYRNE, ANNE-MARIE; REYNOLDS, JOHN (2017) -
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.
LONG, AIDEEN; DUNICAN, DARA JAMES (Nature, 2011)Deubiquitinating enzymes are now emerging as potential therapeutic targets that control many cellular processes, but few have been demonstrated to control cell motility. Here, we show that ubiquitin-specific protease 17 ... -
Golgi phosphoprotein 2 (GOLPH2) is a novel bile acid-responsive modulator of oesophageal cell migration and invasion
BYRNE, ANNE-MARIE; FINN, STEPHEN; REYNOLDS, JOHN; LONG, AIDEEN (2015)Background: The aetiology of Barrett’s oesophagus (BO) and oesophageal cancer is poorly understood. We previously demonstrated that Golgi structure and function is altered in oesophageal cancer cells. A Golgi-associated ... -
Neurofilament expression in human T lymphocytes
FEIGHERY, CONLETH FRANCIS; KELLEHER, DERMOT P; LONG, AIDEEN; MURPHY, ANNE (British Society for Immunology, 1993)The expression of intermediate filaments in normal cells is mainly determined by their embryonal developmental origin. Flow cytometry using monoclonal antibody RT97 demonstrated that neurofilament was detectable in the ... -
New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
LONG, AIDEEN; GILMER, JOHN; EHRHARDT, CARSTEN; WANG, JUN; SALOMON, JOHANNA JESSICA; MAJER, FERENC; KEAVENY, RAYMOND; SHARMA, RUCHIKA (2012)Deoxycholic acid (DCA), a secondary bile acid (BA), and ursodeoxycholic acid (UDCA), a tertiary BA, cause opposing effects in vivo and in cell suspensions. Fluorescent analogues of DCA and UDCA could help investigate ... -
New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid.
KELLEHER, DERMOT; DUGGAN, SHANE; LONG, AIDEEN (2014)We have prepared a new panel of 23 BA derivatives of DCA, chenodeoxycholic acid (CDCA) and lithocholic acid (LCA) in order to study the effect of dual substitution with 3-azido and 24- amidation, features individually ... -
Regulation of Protein Kinase C function by phosphorylation on conserved and non-conserved sites
LONG, AIDEEN; FREELEY, MICHAEL GERARD; KELLEHER, DERMOT P (Elsevier, 2011)Protein Kinase C (PKC) is a family of serine/threonine kinases whose function is influenced by phosphorylation. In particular, three conserved phosphorylation sites known as the activation-loop, the turn-motif and the ... -
The role of chemokines in acute and chronic hepatitis C infection.
DEMPSEY, ENDA; LONG, AIDEEN (2014)Hepatitis C imposes a significant burden on global healthcare. Chronic infection is associated with progressive inflammation of the liver which typically manifests in cirrhosis, organ failure and cancer. By virtue of ... -
Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11
STEVENSON, NIGEL; LONG, AIDEEN; O'FARRELLY, CLIONA; ONG, SEOW (2010)Suppressors of cytokine signalling (SOCS) proteins regulate signal transduction, but their role in responses to chemokines remains poorly understood. We report that cells expressing SOCS1 and 3 exhibit enhanced adhesion ... -
Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism
GILMER, JOHN; LONG, AIDEEN; Sharma, Ruchika; Quilty, Francis; Byrne, Anne-Marie (2017)Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids ...