Browsing by Author "LAWLER, MARK"
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Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
LAWLER, MARK; WILLIAMS, DAVID CLIVE; NATHWANI, SEEMA; MEEGAN, MARY JANE; ZISTERER, DANIELA MARIA (Springer, 2010)Advanced hormone-refractory prostate cancer is associated with poor prognosis and limited treatment options. Members of the pyrrolo-1,5-benzoxazepine (PBOX) family of compounds exhibit anti-cancer properties in cancer cell ... -
The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers.
DUNNE, BARBARA; LYNCH, THOMAS H; PERRY, ANTOINETTE; MARIGNOL, LAURE; HOLLYWOOD, DONAL; LAWLER, MARK; LOFTUS, BARBARA MARY; TEWARI, PRERNA (2009)We investigated the role of the C1772T polymorphisms in exon 12 of the Hypoxia-inducible factor-1 alpha (HIF-1alpha) gene C1772T genotype in prostate cancer (PCa) and amplification of the hypoxic response. We identified ...