Browsing by Author "KHAN, AMIR"
Now showing items 1-6 of 6
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Crystal Structure of NAD-dependent Peptoniphilus Asaccharolyticus Glutamate Dehydrogenase Reveals Determinants of Cofactor Specificity
KHAN, AMIR (2012)Glutamate dehydrogenases (EC 1.4.1.2?4) catalyse the oxidative deamination of l-glutamate to ?-ketoglutarate using NAD(P) as a cofactor. The bacterial enzymes are hexamers and each polypeptide consists of an N-terminal ... -
Mapping the interactions between a RUN domain from DENND5/Rab6IP1 and sorting nexin 1.
KHAN, AMIR; FRANKLIN, EDWARD (2012)Eukaryotic cells have developed a diverse repertoire of Rab GTPases to regulate vesicle trafficking pathways. Together with their effector proteins, Rabs mediate various aspects of vesicle formation, tethering, docking ... -
Structural biology of arf and rab GTPases' effector recruitment and specificity
KHAN, AMIR (2013)Arf and Rab proteins, members of small GTPases superfamily, localize to specific subcellular compartments and regulate intracellular trafficking. To carry out their cellular functions, Arfs/Rabs interact with numerous and ... -
Structure-function analyses of the interactions between Rab11 and Rab14 small GTPases with their shared effector Rab coupling protein (RCP)
BOND, URSULA; KHAN, AMIR (2015)Rab GTPases recruit effector proteins, via their GTP-dependent switch regions, to distinct subcellular compartments. Rab11 and Rab25 are closely related small GTPases that bind to common effectors termed the Rab11 family ...