Browsing by Author "KENNY, ELAINE"
Now showing items 1-14 of 14
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Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.
QUINN, EMMA; KENNY, ELAINE; CORVIN, AIDEN; GILL, MICHAEL; MORRIS, DEREK (2010)Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases, such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes with specific brain functions. Under these ... -
Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing.
MORRIS, DEREK; O'FARRELLY, CLIONA; BRADLEY, DANIEL; KENNY, ELAINE (2012)Campylobacter jejuni is the most common cause of human bacterial gastroenteritis and is associated with several post-infectious manifestations, including onset of the autoimmune neuropathy Guillain-Barre syndrome, causing ... -
Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing.
HARDIMAN, ORLA; CORVIN, AIDEN; MORRIS, DEREK; MCLAUGHLIN, RUSSELL; KENNY, ELAINE (2013) -
Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders.
CORVIN, AIDEN; HERON, ELIZABETH; GILL, MICHAEL; DONOHOE, GARY; ANNEY, RICHARD; GALLAGHER, LOUISE; MORRIS, DEREK; TROPEA, DANIELA; KENNY, ELAINE (2014) -
Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.
GILL, MICHAEL; MORRIS, DEREK; KENNY, ELAINE; CORVIN, AIDEN (2012)Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of _1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated ... -
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.
GILL, MICHAEL; GALLAGHER, LOUISE; ANNEY, RICHARD; KENNY, ELAINE (2011)Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies ... -
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
GILL, MICHAEL; DONOHOE, GARY; KENNY, ELAINE (2013)Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use ... -
Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows.
MORRIS, DEREK; O'FARRELLY, CLIONA; NARCIANDI MARTIN, FERNANDO; KENNY, ELAINE (2012) -
An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; DONOHOE, GARY; TROPEA, DANIELA; KENNY, ELAINE (2014) -
Multiplex Target Enrichment Using DNA Indexing for Ultra-High Throughput SNP Detection.
KENNY, ELAINE; GILKS, WILLIM PETER; CORMICAN, PAUL; MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL; PINTO, CARLOS (2011)Screening large numbers of target regions in multiple DNA samples for sequence variation is an important application of next-generation sequencing but an efficient method to enrich the samples in parallel has yet to be ... -
Mycobacterial PIMs Inhibit Host Inflammatory Responses through CD14-Dependent and CD14-Independent Mechanisms
O'NEILL, LUKE ANTHONY JOHN; KENNY, ELAINE (2011)Mycobacteria develop strategies to evade the host immune system. Among them, mycobacterial LAM or PIMs inhibit the expression of pro-inflammatory cytokines by activated macrophages. Here, using synthetic PIM analogues, we ... -
New data and an old puzzle: The negative association between schizophrenia and rheumatoid arthritis
CORVIN, AIDEN; DONOHOE, GARY; GILL, MICHAEL; KENNY, ELAINE (2015)Background: A long-standing epidemiological puzzle is the reduced rate of rheumatoid arthritis (RA) in those with schizophrenia (SZ) and vice versa. Traditional epidemiological approaches to determine if this negative ...