Browsing by Author "KELLY, DANIEL"
Now showing items 1-20 of 81
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Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation.
(2014)Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) can be leveraged to generate bone in vivo by executing an endochondral program, leading to increased interest in the use of such hypertrophic grafts ... -
An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue
(2012)Inelastic phenomena such as softening and unrecoverable inelastic strains induced by loading have been observed experimentally in soft tissues such as arteries. These phenomena need to be accounted for in constitutive ... -
Apparent behaviour of charged and neutral materials with ellipsoidal fibre distributions and cross-validation of finite element implementations
(2012)Continuous fibre distribution models can be applied to a variety of biological tissues with both charged and neutral extracellular matrices. In particular, ellipsoidal models have been used to describe the complex material ... -
Biochemical Markers of the Mechanical Quality of Engineered Hyaline Cartilage
(Springer, 2007)The aim of this study was to determine whether or not biochemical markers can be used as surrogate measures for the mechanical quality of tissue engineered cartilage. The biochemical composition of tissue engineered ... -
Biomaterial based modulation of macrophage polarization: A review and suggested design principles
(2015)Macrophages have long been known for their phagocytic capabilities and immune defence; however, their role in healing is being increasingly recognized in recent years due to their ability to polarize into pro-inflammatory ... -
Biomechanics of ossiculoplasty
(Rila, 2003)Many different designs of prostheses are available for middle ear surgery. Clinical comparisons of such prostheses are often difficult because of the large number of variables involved in the clinical outcome; including ... -
Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure
(2012)Both hydrostatic pressure (HP) and cell-matrix interactions have independently been shown to regulate the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to test the hypothesis ... -
Chondrogenesis and integration of mesenchymal stem cells within an in vitro cartilage defect repair model
(2009)Integration of repair tissue is a key indicator of the long-term success of cell-based therapies for cartilage repair. The objective of this study was to compare the in vitro chondrogenic differentiation and integration ... -
A comparative study of shear stresses in collagen-GAG and calcium phosphate scaffolds in bone tissue-engineering bioreactors
(Mary Ann Liebert, 2008)The increasing demand for bone grafts combined with their limited availability and potential risks has led to much new research in bone tissue engineering. Current strategies of bone tissue engineering commonly utilize ... -
A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes.
(2014)Despite an increased interest in the use of hydrogel encapsulation and cellular self-assembly (often termed "self-aggregating" or "scaffold-free" approaches) for tissue-engineering applications, to the best of our knowledge, ... -
The Composition of Engineered Cartilage at the Time of Implantation Determines the Likelihood of Regenerating Tissue with a Normal Collagen Architecture.
(2013)The biomechanical functionality of articular cartilage is derived from both its biochemical composition and the architecture of the collagen network. Failure to replicate this normal Benninghoff architecture in regenerating ... -
Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad
(2011)The objective of this study was to determine the functional properties of cartilaginous tissues generated by porcine MSCs isolated from different tissue sources, and to compare these properties to those derived from ... -
Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents.
(2010)The design of medical devices could be very much improved if robust tools were available for computational simulation of tissue response to the presence of the implant. Such tools require algorithms to simulate the response ... -
Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad.
(2014)The objective of this study was to investigate how joint specific biomechanical loading influences the functional development and phenotypic stability of cartilage grafts engineered in vitro using stem/progenitor cells ... -
Defining the impaction frequency and threshold force required for femoral impaction grafting in revision hip arthroplasty. A human cadaveric mechanical study.
(2011)BACKGROUND AND PURPOSE: The two most common complications of femoral impaction bone grafting are femoral fracture and massive implant subsidence. We investigated fracture forces and implant subsidence rates in embalmed ...
