Browsing by Author "KELLEHER, DERMOT P"
Now showing items 1-20 of 55
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Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity
DAVIES, ANTHONY; VOLKOV, YURI; WILLIAMS, YVONNE; PRINA MELLO, ADRIELE; KELLEHER, DERMOT P (2011)Background: Nanomaterials such as SiO2 nanoparticles (SiO2NP) are finding increasing applications in the biomedical and biotechnological fields such as disease diagnostics, imaging, drug delivery, food, cosmetics and ... -
Chronic granulomatous disease presenting as an oculomucocutaneous syndrome mimicking Behcet's syndrome
FEIGHERY, CONLETH FRANCIS; GRIFFIN, MAIREAD; KELLEHER, DERMOT P; MCCANN, SHAUN (BMJ, 1986)A female patient who presented for the first time at the age of 19 with oculomucocutaneous syndrome was found to have an absolute deficiency of neutrophil peroxide production. Neutrophil peroxide production as measured by ... -
Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease
KELLEHER, DERMOT P (BMJ, 1989)T helper and suppressor cell control of autologous immunoglobulin production was measured in 14 patients with Crohn's disease (CD) using autologous B cells or monocytes to stimulate regulatory T-cell activity. A pronounced ... -
Detection of a Tyrosine Phosphatase LAR on Intestinal Epithelial Cells and Intraepithelial Lymphocytes in the Human Duodenum.
KELLEHER, DERMOT P; MURPHY, ANNE; SHEILS, ORLA (Hindawi, 2005)Studies of tyrosine phosphorylation in the human duodenum have indicated that proliferating cells in the middle portion of the duodenal crypt were devoid of this feature, suggesting that tyrosine kinase activation is not ... -
A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors
WINDLE, HENRY; GILMER, JOHN FRANCIS; KELLEHER, DERMOT P; KEOGH, BRIAN; REILLY, MARY (2011)The design, synthesis and delivery potential of a new type of benzenesulfonamide cyclo-oxygenase-2 (COX-2) inhibitor prodrug is investigated using celecoxib. The approach involves a double prodrug that is activated first ... -
The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn's disease have autoantibodies to type VII collagen
KELLEHER, DERMOT P; WEIR, DONALD (Nature, 2002)Epidermolysis bullosa acquisita is an autoimmune blistering disease of the skin characterized by IgG autoantibodies against type VII collagen. Systemic diseases are often associated with epidermolysis bullosa acquisita, ... -
Evaluation of renal function following treatment with 5-aminosalicylic acid derivatives in patients with ulcerative colitis
KELLEHER, DERMOT P; WEIR, DONALD (John Wiley, 2002)BACKGROUND: A number of cases of nephrotoxicity have been reported in patients with inflammatory bowel disease taking oral 5-aminosalicylic acid (5-ASA). AIM: To evaluate the effects of 9 months of therapy with mesalazine ...