Browsing by Author "Healy, Anne-Marie"
Now showing items 1-19 of 19
-
The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus? dry powder inhaler
Healy, Anne-Marie; Reilly, Richard; O'Connell, Peter (2014)Some patients are unable to generate the peak inspiratory flow rate (PIFR) necessary to de-agglomerate drug particles from dry powder inhalers (DPIs). In this study we tested the hypothesis that the acoustic parameters of ... -
Amorphous solid dispersions of ketoprofen and poly-vinyl polymers prepared via electrospraying and spray drying: A comparison of particle characteristics and performance.
Healy, Anne-Marie (Elsevier, 2019-07-20)The purpose of this work was to compare the particle characteristics and dissolution performance of amorphous solid dispersions (ASDs) of ketoprofen and vinyl-pyrrolidone based polymers prepared using electrospraying and ... -
Cocrystal habit engineering to improve drug dissolution and alter derived powder properties
Healy, Anne-Marie; O'Connell, Peter (2016)Objectives: Cocrystallization of sulfadimidine (SDM) with suitable coformers, such as 4-aminosalicylic acid (4-ASA), combined with changes in the crystal habit can favourably alter its physicochemical properties. The aim ... -
A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products.
Healy, Anne-Marie (2018)The purpose of this work was to investigate the application of different advanced continuous processing techniques (hot melt extrusion and spray drying) to the production of fixed-dose combination (FDC) monolithic systems ... -
Comparison of wet milling and dry milling routes for ibuprofen pharmaceutical crystals and their impact on pharmaceutical and biopharmaceutical properties
Healy, Anne-Marie; Padamati, Ramesh (2018-05)The development of solid dosage forms and manufacturing processes are governed by complex physical properties of the powder and the type of pharmaceutical unit operation the manufacturing processes employs. Suitable powder ... -
Development and characterisation of soluble polymeric particles for pulmonary peptide delivery
Healy, Anne-Marie; Ehrhardt, Carsten; Corrigan, Owen; Tajber, Lidia (2010)Pulmonary administration of protein and peptide drugs using inhaled dry powder particles is an interesting alternative to parenteral delivery. The stabilisation of these molecules is essential to the maintenance of biological ... -
Development and characterization of dapsone cocrystal prepared by scalable production methods
Healy, Anne-Marie (American Association of Pharmaceutical Scientists ; Springer Verlag, 2018)In this study, the formation of caffeine:dapsone (CAF:DAP) cocrystals by scalable production methods, such as liquid assisted grinding (LAG) and spray drying, was investigated in the context of the potential use of processed ... -
Development of a new formulation of roflumilast for pulmonary drug delivery to treat inflammatory lung conditions.
Healy, Anne-Marie (2018-10-25)The aim of this study was to develop roflumilast dry powder inhaler (DPI) formulations by spray drying using hydroxypropyl-β-cyclodextrin (HPβCD) and to determine their suitability for pulmonary delivery. Different feed ... -
Development of inhaled formulation of modified clofazimine as an alternative to treatment of tuberculosis: Clofazimine inhaled formulation for tuberculosis
Healy, Anne-Marie (2020)Inhalation drug delivery provides a possible useful alternative to oral drug delivery in the treatment of tuberculosis (TB). This work evaluated inclusion complexes of clofazimine (CFZ), an anti-TB drug with low aqueous ... -
Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion.
Healy, Anne-Marie; O'Connell, Peter (2018)The comparison of spray drying versus hot melt extrusion (HME) in order to formulate amorphous solid dispersions has been widely studied. However, to the best of our knowledge, the use of both techniques to form cocrystals ... -
Impact of substrate properties on the formation of spherulitic films: a case study of salbutamol sulfate
Healy, Anne-Marie; Tajber, Lidia; O'Connell, Peter (2016)Spherulitic assemblies have applications as carriers for drug delivery and as targeting vectors. Presently, the driving force behind the formation of spherulites comprising small drug molecules is not fully understood. ... -
In Situ Cocrystallization of Dapsone and Caffeine during Fluidized Bed Granulation Processing
Healy, Anne-Marie (American Association of Pharmaceutical Scientists ; Springer Verlag, 2019-01)Different pharmaceutical manufacturing processes have been demonstrated to represent feasible platforms for the production of pharmaceutical cocrystals. However, new methods are needed for the manufacture of cocrystals on ... -
Metformin Hydrochloride and Sitagliptin Phosphate Fixed-Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology
Healy, Anne-Marie (2020)The development of oral solid dosage forms, such as tablets that contain a high dose of drug(s), requires polymers and other additives to be incorporated at low levels as possible, to keep the final tablet weight low, and, ... -
Mitigating unwanted amorphisation: A screening method for the selection of suitable excipients
Healy, Anne-Marie; O'Connell, Peter (2016)Co-processing an active pharmaceutical ingredient (API) with a low Tg excipient has been previously reported to be an effective strategy for preventing drug amorphisation on milling. This technique relies on the ability ... -
Modelling and understanding powder flow properties and compactability of selected active pharmaceutical ingredients, excipients and physical mixtures from critical material properties
Healy, Anne-Marie; Worku, Zelalem; O'Connell, Peter (2017)The development of solid dosage forms and manufacturing processes are governed by complex physical properties of the powder and the type of pharmaceutical unit operation the manufacturing processes employs. Suitable powder ... -
Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating
Healy, Anne-Marie; O'Connell, Peter (2018)Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the ... -
Pharmaceutical solvates, hydrates and amorphous forms: a special emphasis on cocrystals
Healy, Anne-Marie; Worku, Zelalem; Madi, Atif (2017) -
Polymorphism in sulfadimidine/4-aminosalicylic acid cocrystals: solid state characterization and physicochemical properties
Healy, Anne-Marie; O'Connell, Peter (2015) -
Production of cocrystals in an excipient matrix by spray drying
Healy, Anne-Marie (2018-01)Spray drying is a well-established scale-up technique for the production of cocrystals. However, to the best of our knowledge, the effect of introducing a third component into the feed solution during the ...