Browsing by Author "HOLLAND, CELIA"
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Ascaris and ascariasis
DOLD, CHRISTINA; HOLLAND, CELIA (2011)Ascaris lumbricoides and Ascaris suum are widespread parasitic nematodes of humans and pigs respectively. Recent prevalence data suggests that approximately 1.2 billion people are infected. Adult worms exhibit an overdispersed ... -
Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children.
HOLLAND, CELIA (2013)BACKGROUND: Co-infection with malaria and intestinal parasites such as Ascaris lumbricoides is common. Malaria parasites induce a pro-inflammatory immune response that contributes to the pathogenic sequelae, such as ... -
Cerebral toxocariasis: Silent progression to neurogenerative disorders?
HOLLAND, CELIA (2015)Toxocara canis and T. cati are highly prevalent nematode infections of the intestines of dogs and cats. In paratenic hosts, larvae do not mature in the intestine but instead migrate through the somatic tissues and organs ... -
Community study of toxoplasma antibodies in urban and rural schoolchildren aged 4 to 18 years.
HOLLAND, CELIA (BMJ Publishing Group, 1997)To estimate the prevalence of toxoplasma antibodies in schoolchildren and their association with clinical and environmental data, antibody titres were measured in 1276 children aged 4 to 18 years attending primary and ... -
Comparison of the macroparasite communities of stocked and wild trout (Salmo trutta) from the West of Ireland
HOLLAND, CELIA (2002)The aim of the present study was to compare the helminth infra and component communities of wild and stocked brown trout in Lough Feeagh, in the west of Ireland, and also to examine the establishment and development of ... -
Contamination of the hair of owned dogs with the eggs of Toxocara spp
HOLLAND, CELIA (2010)Toxocara canis is one of the most common gastrointestinal helminthes of dogs. Humans can become infected through ingestion of infective eggs, Infection often causes few symptoms but in rare cases blindness can occur. It ... -
The development of a mouse model to explore resistance and susceptibility to early Ascaris suum infection
HOLLAND, CELIA; STAFFORD, PETER (2006)Ascaris suum and Ascaris lumbricoides exhibit an over-dispersed frequency distribution in their host populations in both the adult and larval stages. The impact of host factors on this observed distribution is still poorly ... -
Dose-dependent impact of larval Ascaris suum on host body weight in the mouse model
HOLLAND, CELIA; STAFFORD, PETER (2009)Ascaris lumbricoides and Ascaris suum are important helminth parasites of humans and pigs, respectively. Although it is now well established that the presence of mature adult worms in the host intestine contributes to ... -
Genetic influence on the kinetics and associated pathology of the early stage (intestinal-hepatic) migration of Ascaris suum in mice
HOLLAND, CELIA; STAFFORD, PETER (2010)The generative mechanism(s) of aggregation and predisposition to Ascaris lumbricoides and A. suum infections in their host population are currently unknown and difficult to elucidate in humans and pigs for ethical/logistical ... -
Identification of a high diversity of Cryptosporidium species, genotypes and subtypes in a Nigerian Pediatric Population
HOLLAND, CELIA (2010)A longitudinal study was conducted to determine the epidemiology of Cryptosporidium in 1,636 children in Nigeria. Oocyst prevalence ranged from 15.6% to 19.6% over one year. Cryptosporidium hominis (34), C. parvum (25), ... -
Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial
JACKSON, ANDREW; HOLLAND, CELIA; MOLLOY, SILE (2010)Background: Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections in preschool children. Methods: A double-blind ... -
The influence of inoculum size and time post-infection on the number and position of Toxocara canis larvae recovered from the brains of outbred CD1 mice
HOLLAND, CELIA; STAFFORD, PETER (2001)Outbred CD1 mice were administered doses of 1000 and 3000 Toxocara canis eggs and postmortem took place on days 7, 42 and 120 post-infection. Mice were killed by cervical dislocation and brains were sagitally bisected and ... -
The influence of mouse strain, infective dose and larval burden in the brain on activity in Toxocara-infected mice
HOLLAND, CELIA (2001)Outbred LACA mice and inbred NIH mice were administered low (100 ova), medium (1000 ova), high (3000 ova) and trickle (4x250 ova) doses of Toxocara canis ova and the effect of infection on activity was examined with respect ... -
Interspecific interactions between Acanthocephala in the intestine of brown trout : are they more frequent in Ireland?
HOLLAND, CELIA (2003)The aim of this paper was to test the hypothesis that when the 2 species of Acanthocephalan Pomphorhynchus laevis and Acanthocephalus clavula are found concurrently within the intestine of brown trout under field conditions, ... -
Investigating the underlying mechanism of resistance to Ascaris infection
DOLD, CHRISTINA; HOLLAND, CELIA (2011)The generative mechanism(s) of predisposition to Ascaris infection are currently unknown. While many factors play a role in interindividual infection intensity, much focus has been placed on the host's immunological response ... -
The migration of Ascaris suum larvae, and the associated pulmonary inflammatory response in susceptible C57BL/6j and resistant CBA/Ca mice
HOLLAND, CELIA; STAFFORD, PETER (2007)Ascariasis is an important infection in humans (Ascaris lumbricoides) and pigs (Ascaris suum) and individuals appear to be predisposed to either heavy or light worm burdens. These extremes of susceptibility and resistance ... -
A murine model for cerebral toxocariasis: characterisation of host susceptibility and behaviour.
HOLLAND, CELIA; STAFFORD, PETER (2006)Toxocara canis, the parasitic roundworm of dogs, can infect a number of paratenic hosts, such as mice and humans, due to the widespread dissemination of its ova in the environment. In these paratenic hosts, larvae have ... -
Natural immunity to Ascaris lumbricoides associated with IgE antibody to ABA-1 allergen and inflammatory indicators in children
HOLLAND, CELIA (American Society for Microbiology, 1999)Children putatively immune to the large roundworm Ascaris lumbricoides were identified in an area of Nigeria where infection is hyperendemic. Immunity was associated with higher levels of serum ferritin, C-reactive protein, ... -
Ocular toxocariasis in school children
HOLLAND, CELIA (2004)Ocular toxocariasis in humans is typically a unilateral disease caused by second?stage larvae of the Toxocara species. Serological evidence of widespread infection in humans provides little information on clinical disease. ... -
Patterns of soil-transmitted helminth infection and impact of four-monthly albendazole treatments in preschool children from semi-urban communities in Nigeria: a double-blind placebo-controlled randomised trial.
JACKSON, ANDREW; HOLLAND, CELIA; MOLLOY, SILE (2009)BACKGROUND: Children aged between one and five years are particularly vulnerable to disease caused by soil-transmitted helminths (STH). Periodic deworming has been shown to improve growth, micronutrient status (iron and ...