Browsing by Author "HOKAMP, KARSTEN"
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Cell envelope gene expression in phosphate-limited Bacillus subtilis cells.
BOTELLA, ERIC; DEVINE, KEVIN; HOKAMP, KARSTEN (2011)The high phosphate content of Bacillus subtilis cell walls dictates that cell wall metabolism is an important feature of the PhoPR-mediated phosphate limitation response. Here we report the expression profiles of ... -
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression
STREUBEL, GUNDULA; HOKAMP, KARSTEN (2013)The chromatin remodeler CHD5 is expressed in neu- ral tissue and is frequently deleted in aggressive neuroblastoma.Verylittleisknownaboutthefunction of CHD5 in the nervous system or its mechanism of action. Here we ... -
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.
CURTIS, ANNIE; O'NEILL, LUKE; HOKAMP, KARSTEN (2015)The circadian clock allows an organism to anticipate daily changes imposed by the environment. The response to LPS is altered depending on time of day; however, the molecular mechanisms underlying this are unclear. We find ... -
Compensatory evolution of gene regulation in response to stress by Escherichia coli lacking RpoS.
DORMAN, CHARLES JAMES; HOKAMP, KARSTEN (2009)The RpoS sigma factor protein of Escherichia coli RNA polymerase is the master transcriptional regulator of physiological responses to a variety of stresses. This stress response comes at the expense of scavenging for ... -
The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns.
MITCHELL, KEVIN; DOLAN, JACKIE; HOKAMP, KARSTEN; OKAFUJI, TATSUYA (2007)BACKGROUND: Leucine-rich repeats (LRRs) are highly versatile and evolvable protein-ligand interaction motifs found in a large number of proteins with diverse functions, including innate immunity and nervous system development. ... -
Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes
O'FARRELLY, CLIONA; HOKAMP, KARSTEN (2011)Background: Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), a pathological infection with significant economic impact. Recent studies have highlighted the role of functional genomics to better ... -
Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis
HOKAMP, KARSTEN (2012)BACKGROUND: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cell types to encounter M. bovis following exposure ... -
An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium.
HOKAMP, KARSTEN; KROGER, CARSTEN (2013)Bacterial transcriptional networks consist of hundreds of transcription factors and thousands of promoters. However, the true complexity of transcription in a bacterial pathogen and the effect of the environments encountered ... -
A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni.
HOKAMP, KARSTEN (2014)Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira . More than 500,000 cases of severe leptospirosis are reported annually, with . 10% ... -
PubCrawler: keeping up comfortably with PubMed and GenBank
HOKAMP, KARSTEN; WOLFE, KENNETH (Oxford University Press, 2004)The free PubCrawler web service (http://www.pubcrawler.ie) has been operating for five years and so far has brought literature and sequence updates to over 22 000 users. It provides information on a personalized web page ... -
RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium bovis.
HOKAMP, KARSTEN; O'FARRELLY, CLIONA (2014)Bovine tuberculosis, caused by infection with Mycobacterium bovis, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many ... -
Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits.
HARAN, JOHN; FLEMING, ALASTAIR; HOKAMP, KARSTEN (2014)The TLO genes are a family of telomere-associated ORFs in the fungal pathogens Candida albicans and C. dubliniensis that encode a subunit of the Mediator complex with homology to Med2. The more virulent pathogen C. ... -
Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro
HOKAMP, KARSTEN (BioMed Central Ltd, 2013)Background Mycobacterium bovis, the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during infection via a diverse range of mechanisms that subvert the host ...