Browsing by Author "HIGGINS, SARAH"
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Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells GALVIN, KAREN; HIGGINS, SARAH; MILLS, KINGSTON; STEFANSKA, ANNA; MORAN, BARRY; DUNGAN, LARA (2013)The immune system has evolved regulatory mechanisms to control immune responses to self-antigens. Regulatory T (Treg) cells play a pivotal role in maintaining immune tolerance, but tumour growth is associated with local ...
Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine. MCLOUGHLIN, RACHEL; LAVELLE, EDWARD; MILLS, KINGSTON; SUTTON, CAROLINE; HIGGINS, SARAH; ALLEN, AIDEEN (2013)Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa). One explanation for this is that Pa are less protective than the ...
The role of regulatory T cells in respiratory infections and allergy and asthma HIGGINS, SARAH; MILLS, KINGSTON (2010)The role of distinct CD4+ T cell populations in regulating the nature and strength of immune responses is well documented, and in the past has principally focused on the cross regulation of Th1 and Th2 cells, which secrete ...
TLR, NLR agonists, and other immune modulators as infectious disease vaccine adjuvants MILLS, KINGSTON; HIGGINS, SARAH (2010)Vaccines based on attenuated or killed viruses and bacteria are highly effective in preventing infection with a range of pathogens, but can have safety issues. Therefore, there is a move towards subunit vaccines based ...