Browsing by Author "HAMPEL, HARALD"
Now showing items 1-14 of 14
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Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging
HAMPEL, HARALD (Elsevier, 2009)Healthy aging is associated with brain volume reductions that involve the frontal cortex, but also affect other brain regions. We sought to identify an age-related network pattern of MRI gray matter using a multivariate ... -
Altered Brain Activation During a Verbal Working Memory Task in Subjects with Amnestic Mild Cognitive Impairment.
BOKDE, ARUN; HAMPEL, HARALD (2010)In subjects with Mild Cognitive Impairment (MCI) memory disorders indicate a high risk for conversion to Alzheimer?s disease (AD). The objective of this study was to delineate the differences in brain activation between ... -
Amyloid ? peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
HAMPEL, HARALD (Elsevier, 2009)We measured concentrations of A? peptides 1?42 and 1?40, and their ratio in plasma of patients carefully categorized clinically and neurochemically as having AD or other dementias with a newly commercially available ... -
Assessing neuronal networks: Understanding Alzheimer's disease
HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN (2009)Findings derived from neuroimaging of the structural and functional organization of the human brain have led to the widely supported hypothesis that neuronal networks of temporally coordinated brain activity across different ... -
Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease
HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN (2010)Subjects with mild cognitive impairment (MCI) have an increased risk to develop Alzheimer?s disease (AD). Voxel-based MRI studies have demonstrated that widely distributed cortical and subcortical brain areas show atrophic ... -
Decreased activation along the dorsal visual pathway after a 3-month treatment with Galantamine in mild Alzheimer's disease
HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN (Wolters Kluwer, 2009)Visual perception has been shown to be altered in Alzheimer?s disease (AD) patients and it is associated with decreased cognitive function. Galantamine is an active cholinergic agent, which has been shown to lead to ... -
Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease.
BOKDE, ARUN; HAMPEL, HARALD (2012)Functional magnetic resonance imaging (fMRI) of default mode network (DMN) brain activity during resting is recently gaining attention as a potential noninvasive biomarker to diagnose incipient Alzheimer's disease. The aim ... -
Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease.
BOKDE, ARUN LAWRENCE WARREN; HAMPEL, HARALD (Elsevier, 2011)During the last two decades, imaging of neural activation has become an invaluable tool for assessing the functional organization of the human brain in vivo. Due to its widespread application in neuroscience, functional ... -
Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease
HAMPEL, HARALD (Elsevier, 2010)Magnetic resonance imaging (MRI)-based volumetry of medial temporal lobe regions is among the best established biomarker candidates of Alzheimer's disease (AD) to date. This study assessed the effect of multicentre variability ... -
Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer s Disease
COUGHLAN, TARA LEAH; BOKDE, ARUN LAWRENCE WARREN; COLLINS, DANIEL RONAN; O'NEILL, DESMOND; HAMPEL, HARALD; TANNER, COLBY; BARTLEY, MAIREAD MARY (PLoS, 2011)The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, ... -
On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia
BOKDE, ARUN LAWRENCE WARREN; BEDE, PETER; HAMPEL, HARALD; HARDIMAN, ORLA (Elsevier, 2011)Pathological 43-kDa transactive responsive sequence DNA-binding protein (TDP-43) has been recognized as the major disease protein in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin ... -
Recent developments of functional magnetic resonance imaging research for drug development in Alzheimer's disease
BOKDE, ARUN; HAMPEL, HARALD (2011)The objective of this review is to evaluate recent advances in functional magnetic resonance imaging (fMRI) research in Alzheimer's disease for the development of therapeutic agents. The basic building block underpinning ... -
Total and phosphorylated Tau protein as biological markers of Alzheimer's disease
HAMPEL, HARALD (Elsevier, 2009)Advances in our understanding of tau-mediated neurodegeneration in Alzheimer?s disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts. ... -
White matter microstructure underlying default mode network connectivity in the human brain
HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN (2010)Resting state functional magnetic resonance imaging (fMRI) reveals a distinct network of correlated brain function representing a default mode state of the human brain. The underlying structural basis of this functional ...