Browsing by Author "GILMER, JOHN FRANCIS"
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A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors
WINDLE, HENRY; GILMER, JOHN FRANCIS; KELLEHER, DERMOT P; KEOGH, BRIAN; REILLY, MARY (2011)The design, synthesis and delivery potential of a new type of benzenesulfonamide cyclo-oxygenase-2 (COX-2) inhibitor prodrug is investigated using celecoxib. The approach involves a double prodrug that is activated first ... -
In-vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin?
GILMER, JOHN FRANCIS; HARMON, SHONA; Jones, Michael (2012)Objectives: To evaluate the pharmacokinetics and effects of the first immediate-release (IR) niacin-aspirin prodrug (ST0702) on lipid, prostaglandin and thromboxane levels in non-human primates (NHPs). Methods: We ...