Browsing by Author "Flis, Ewelina"

Now showing items 1-2 of 2

    • Caspase-11 promotes allergic airway inflammation 

      Creagh, Emma; Lavelle, Edward; O'Neill, Luke; Mills, Kingston; Zasłona, Zbigniew; Flis, Ewelina; Wilk, Mieszko M.; Carroll, Richard G.; Palsson-McDermott, Eva M.; Hughes, Mark M.; Diskin, Ciana; Banahan, Kathy; Ryan, Dylan G.; Hooftman, Alexander; Misiak, Alicja; Kearney, Jay; Lochnit, Gunter; Bertrams, Wilhelm; Greulich, Timm; Schmeck, Bernd; McElvaney, Oliver J.; Wygrecka, Małgorzata (2020)
      Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 ...

    • Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis 

      Creagh, Emma; Mills, Kingston; Flood, Brie; Manils, Joan; Nulty, Ciara; Flis, Ewelina; Kenealy, Sinead; Barber, Gillian; Fay, Joanna; Kay, Elaine (2019)
      Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for the ...