Browsing by Author "FAYNE, DARREN"
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Identification of Plasmepsin Inhibitors as Selective Antimalarial Agents using Ligand Based Drug Design
DEMPSEY, ENDA; LLOYD, DAVID G; CARTA, GIORGIO; FAYNE, DARREN; BELL, ANGUS (Elsevier, 2011)We describe the application of Ligand Based Virtual Screening technologies towards the discovery of novel Plasmepsin (PM) inhibitors, a family of malarial parasitic aspartyl proteases. Pharmacophore queries were used to ... -
Novel Microtubule targetting agents, pyrrolo-1,5,benzoxazepines induce apoptosis in multi-drug-resistant cancer cells
LLOYD, DAVID; ZISTERER, DANIELA; WILLIAMS, DAVID; FAYNE, DARREN (2010)PURPOSE: The development of multi-drug resistance (MDR) due to the expression of members of the ATPase binding cassette (ABC) transporter family is a major obstacle in cancer treatment. The broad range of substrate ... -
Rational ligand based drug design and structure-activity relationship studies in the ligand-binding domain of the glucocorticoid receptor ?
FAYNE, DARREN; LLOYD, DAVID G (Future Science, 2009)