Browsing by Author "FARRAR, GWYNETH JANE"
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Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus
HUMPHRIES, PETER; PALFI, ARPAD; CHADDERTON, NAOMI SARAH; FARRAR, GWYNETH JANE; KENNA, PAUL (2012)Recombinant adeno-associated virus (AAV) represents an efficient system for neuronal transduction. However, a potential drawback of AAV is its restricted packaging capacity of approximately 5kb. To bypass this limita- tion, ... -
Mitochondrial disorders: aetiologies, models systems, and candidate therapies
MILLINGTON-WARD, SOPHIA; CHADDERTON, NAOMI SARAH; FARRAR, GWYNETH JANE; KENNA, PAUL (2013)It has become evident that many human disorders are characterised by mitochondrial dysfunction either at a primary level, due to mutations in genes whose encoded products are involved in oxidative phosphorylation, or at a ... -
RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
HUMPHRIES, MARIAN; HUMPHRIES, PETER; FARRAR, GWYNETH JANE (Elsevier, 2007)Mutational heterogeneity represents a significant barrier to development of therapies for many dominantly inherited diseases. For example, >100 mutations in the rhodopsin gene (RHO) have been identified in patients with ...