Browsing by Author "FARES, MARIO"
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ChloroMitoSSRDB: open source repository of perfect and imperfect repeats in organelle genomes for evolutionary genomics.
FARES, MARIO (2013)Microsatellites or simple sequence repeats (SSRs) are repetitive stretches of nucleotides (A, T, G, C) that are distributed either as single base pair stretches or as a combination of two- to six-nucleotides units that are ... -
Coevolution analyses illuminate the dependencies between amino acid sites in the chaperonin system GroES-L.
FARES, MARIO (2013)BACKGROUND: GroESL is a heat-shock protein ubiquitous in bacteria and eukaryotic organelles. This evolutionarily conserved protein is involved in the folding of a wide variety of other proteins in the cytosol, being ... -
Essentiality is a strong determinant of protein rates of evolution during mutation accumulation experiments in Escherichia coli
FARES, MARIO (2016)The Neutral Theory of Molecular Evolution is considered the most powerful theory to understand the evolutionary behavior of proteins. One of the main predictions of this theory is that essential proteins should evolve ... -
Evidence of positively selected sites in mammalian alpha-defensins.
O'FARRELLY, CLIONA; FARES, MARIO; LLOYD, ANDREW (2004)Alpha-defensins are a family of mammalian antimicrobial peptides that exhibit variable activity against a panel of microbes, including bacteria, fungi, and enveloped viruses. We have employed a maximum-likelihood approach ... -
Functional conservation of an ancestral Pellino protein in helminth species
FARES, MARIO; FALLON, PADRAIC (2015)The immune system of H. sapiens has innate signaling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms such as ... -
The molecular chaperone dnak is a source of mutational robustness
FARES, MARIO (2016)Molecular chaperones, also known as heat-shock proteins, refold misfolded proteins and help other proteins reach their native conformation. Thanks to these abilities, some chaperones, such as the Hsp90 protein or the ... -
Mutational dynamics of murine angiogenin duplicates
FARES, MARIO (2010)Background: Angiogenin (Ang) is a protein involved in angiogenesis by inducing the formation of blood vessels. The biomedical importance of this protein has come from findings linking mutations in Ang to cancer progression and ... -
The phenotypic plasticity of duplicated genes in Saccharomyces cerevisiae and the origin of adaptations
FARES, MARIO (2017)Gene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of ... -
Preservation of genetic and regulatory robustness in ancient gene duplicates of Saccharomyces cerevisiae.
FARES, MARIO (2014)Biological systems remain robust against certain genetic and environmental challenges. Robustness allows the exploration of ecological adaptations. It is unclear what factors contribute to increasing robustness. Gene ... -
Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactome
FARES, MARIO (2015)Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying ... -
Survival and innovation: The role of mutational robustness in evolution
FARES, MARIO (2014)Biological systems are resistant to perturbations caused by the environment and by the intrinsic noise of the system. Robustness to mutations is a particular aspect of robustness in which the phenotype is resistant to ... -
The tale of a modern animal plague: Tracing the evolutionary history and determining the time-scale for foot and mouth disease virus
FARES, MARIO (2009)Despite significant advances made in the understanding of its epidemiology, foot and mouth disease virus (FMDV) is among the most unexpected agricultural devastating plagues. While the disease manifests itself as seven ...