Browsing by Author "EHRHARDT, CARSTEN"
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Adhesion characteristics and stability assessment of lectin-modified liposomes for site-specific drug delivery
EHRHARDT, CARSTEN (2008)Carbohydrate moieties of the cellular glycocalyx have been suggested to play an important role in biological recognition processes during pathologic conditions, such as inflammation and cancer. Herein, we describe ... -
Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery
EHRHARDT, CARSTEN; HEALY, ANNE (2016) -
Cytoskeletal re-arrangement in TGF-beta1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis
EHRHARDT, CARSTEN; DAVIES, ANTHONY; MEDINA MARTIN, CARLOS (2012)Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis of idiopathic pulmonary fibrosis. Associated with this phenotypic transition is acquisition of an elongated cell morphology and establishment ... -
Effect of lyophilisation on liposomal systems for the delivery of salmon calcitonin (sCT)
EHRHARDT, CARSTEN (2014) -
Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation
EHRHARDT, CARSTEN; HEALY, ANNE (2015) -
In vivo assessment of parenteral formulations of oligo(3-hydroxybutyric acid) conjugates with the model compound ibuprofen
EHRHARDT, CARSTEN (2010)Polymer-drug conjugates have gained significant attention as pro-drugs releasing an active substance as a result of enzymatic hydrolysis in physiological environment. In this study, a conjugate of 3-hydroxybutyric acid ... -
Interplay between the receptor for advanced glycation end-products (RAGE), CD44 and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells
EHRHARDT, CARSTEN; MEDINA MARTIN, CARLOS; BUCKLEY, STEPHEN (2011) -
Nanodrug applications in photodynamic therapy.
EHRHARDT, CARSTEN; SENGE, MATHIAS; KELLEHER, DERMOT P; REYNOLDS, JOHN (2011) -
Nanoparticles attenuate P-glycoprotein/MDR1 function in A549 human alveolar epithelial cells
SALOMON, JOHANNA JESSICA; EHRHARDT, CARSTEN (2011)P-glycoprotein/MDR1 (P-gp) is a well characterised membrane transporter relevant in drug disposition and multi-drug resistance. In this study, we aimed to investigate in how far nanoparticulates impair the function of the ... -
New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
LONG, AIDEEN; GILMER, JOHN; EHRHARDT, CARSTEN; WANG, JUN; SALOMON, JOHANNA JESSICA; MAJER, FERENC; KEAVENY, RAYMOND; SHARMA, RUCHIKA (2012)Deoxycholic acid (DCA), a secondary bile acid (BA), and ursodeoxycholic acid (UDCA), a tertiary BA, cause opposing effects in vivo and in cell suspensions. Fluorescent analogues of DCA and UDCA could help investigate ... -
The particle has landed - characterizing the fate of inhaled pharmaceuticals
EHRHARDT, CARSTEN (2010)Although there is a modest body of literature on the absorption of inhaled pharmaceuticals by normal lungs and some limited information from diseased lungs, there is still a surprising lack of mechanistic knowledge about ... -
Pulmonary delivered polymeric micelles - pharmacokinetic evaluation and biodistribution studies
EHRHARDT, CARSTEN (2014)Polymeric micelles represent interesting delivery systems for pulmonary sustained release. However, little is known about their in vivo release and translocation profile after delivery to the lungs. In the present study, ... -
The receptor for advanced glycation end-products (RAGE) and the lung
BUCKLEY, STEPHEN; EHRHARDT, CARSTEN (2010)The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules. As a pattern-recognition receptor capable of binding a diverse range of ligands, it is typically ... -
Stability of salmon calcitonin against trypsin, chymotrypsin and neutrophil elastase in human lung epithelial cells
EHRHARDT, CARSTEN; BAGINSKI, EVE LEONIE; BUCKLEY, STEPHEN (2010)At least three enzymes (i. e., trypsin, chymotrypsin and neutrophil elastase) are responsible for the degradation of salmon calcitonin (sCT) in the human body. Here, we investigated how these proteinases affect drug ... -
Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery
TAJBER, LIDIA; EHRHARDT, CARSTEN; PALUCH, KRZYSZTOF; HEALY, ANNE (2013)In a number of pulmonary diseases, patients may develop abnormally viscous mucus reducing drug efficacy. To increase budesonide diffusion within lung fluid, we developed nanoporous microparticles (NPMPs) composed of ... -
Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer
SENGE, MATHIAS; EHRHARDT, CARSTEN; PASZKO, EDYTA (2013)Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol ... -
Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) in human respiratory epithelial cells
SALOMON, JOHANNA; EHRHARDT, CARSTEN; BUCKLEY, STEPHEN (2012)Organic cation/carnitine transporters (OCT/N) mediate uptake of positively charged molecules. Their role in lung epithelium, however, is not well understood. OCT/N expression and activity was studied in cell lines of human ... -
Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism
EHRHARDT, CARSTEN (2012)Peroxisome proliferator activated receptor ? (PPAR?) agonists are effective antifibrotic agents in a number of tissues. Effects of these agents on epithelial-mesenchymal transition (EMT) of primary alveolar epithelial cells ... -
Utilising atomic force microscopy for the characterisation of nanoscale drug delivery systems
EHRHARDT, CARSTEN (2010)