Browsing by Author "Dunne, Margaret"
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Activation of human invariant natural killer T cells with a thioglycoside analogue of ?-galactosylceramide
O'FARRELLY, CLIONA; O'REILLY, VINCENT; Dunne, Margaret; AMU, SYLVIE; FALLON, PADRAIC; DOHERTY, DEREK; ZENG, SHIJUAN GRACE (2011)Activation of CD1d-restricted invariant NKT (iNKT) cells with the glycolipid ?-galactosylceramide (?-GalCer) confers protection against disease in murine models, however, clinical trials in humans have had limited impact. ... -
CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells
Mangan, Bozgana A; Dunne, Margaret; O'Reilly, Vincent P; Dunne, Padraic; Exley, Mark A; O'Shea, Donal; Scotet, Emmanuel; Hogan, Andrew E; Doherty, Derek G (2013) -
CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection.
Rogers, Thomas; Long, Aideen; Dunne, Margaret; Dunne, Pádraic J.; Maher, Christina O.; Freeley, Michael; Dunne, Katie; Petrasca, Andreea; Orikiiriza, Judy; Reidy, Derval; O'Dea, Siobhan; Loy, Aisling; Woo, Jim; Mulcahy, Fiona; Doherty, Derek G. (2018)Human γδ T cells expressing the Vδ1 T cell receptor (TCR) recognize self and microbial antigens and stress-inducible molecules in a major histocompatibility complex-unrestricted manner and are an important source of innate ... -
Characterising the prognostic potential of HLA-DR during colorectal cancer development
Phelan, James; Dunne, Margaret (2020)HLA-DR, an MHC class II molecule that mediates antigen presentation, is a favourable prognostic indicator in colorectal cancer (CRC). However, the dynamics and location of HLA-DR expression during CRC development are ... -
(E)-4-hydroxy-3-methyl-but-2 enyl pyrophosphate-stimulated V?9V?2 T cells possess T helper type 1-promoting adjuvant activity for human monocyte-derived dendritic cells
Dunne, Margaret; Madrigal-Estebas, Laura; Tobin, Laura; Doherty, Derek G (2010) -
HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma patients
Dunne, Margaret; REYNOLDS, JOHN; RAVI, NARAYANASAMY (2017) -
Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma.
Dunne, Margaret; Lynam-Lennon, Niamh; O'Sullivan, Jacintha; Ravi, Narayanasamy (2018)Oesophageal cancer is an aggressive disease with a poor 5 year survival rate of <20% of diagnosed patients. Unfortunately, only 20-30% Oesophageal Adenocarinoma (OAC) patients show a beneficial response to neoadjuvant ... -
Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma?An Emerging Role for Chemokines
Dunne, Margaret; Lysaght, Joanne; Reynolds, John; Ravi, Narayanasamy; Phelan, James (2020)Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis and incidence is increasing rapidly in the Western world. Multi-modal treatment has improved survival outcomes but only for a minority of patients. ... -
Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma
Dunne, Margaret; O'Sullivan, Jacintha; Reynolds, John; Ravi, Narayanasamy; Phelan, James (2019)Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites and ... -
Obesity-associated cancer: an immunological perspective.
CONROY, MELISSA; Dunne, Margaret; Donohoe, Claire L; Reynolds, John V (2015) -
Persistent Changes in Circulating and Intestinal gamma delta T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease
DOHERTY, DEREK; Dunne, Margaret (2013)Coeliac disease is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. The only current therapy is a lifelong gluten free diet. While ... -
Preferential Th1 Cytokine Profile of Phosphoantigen-Stimulated Human V?9V?2 T Cells
Dunne, Margaret; MANGAN, BOZGANA; DOHERTY, DEREK (Hindawi, 2010)Human V?9V?2 T cells recognise pyrophosphate-based antigens (phosphoantigens) and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used ... -
Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib
Dunne, Margaret; Lysaght, Joanne; Reynolds, John; O'Sullivan, Jacintha; Ravi, Narayanasamy (2020)Oesophageal cancer is the 6th most common cause of cancer related death worldwide. The current standard of care for oesophageal adenocarcinoma (OAC) focuses on neoadjuvant therapy with chemoradiation or chemotherapy, however ... -
The tumour microenvironment of the upper and lower gastrointestinal tract differentially influences dendritic cell maturation.
Dunne, Margaret; Lysaght, Joanne; Reynolds, John (2020)Background: Only 10-30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and angiogenic mediators in the tumour microenvironment ...