Browsing by Author "Doyle, Sarah"
Now showing items 1-16 of 16
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Attenuated CSF-1R signalling drives cerebrovascular pathology
Doyle, Sarah; Doherty, Colin; Campbell, Matthew; Brennan, Kiva; Greene, Chris (2021)Cerebrovascular pathologies occur in up to 80% of cases of Alzheimer's disease; however, the underlying mechanisms that lead to perivascular pathology and accompanying blood–brain barrier (BBB) disruption are still not ... -
Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration.
Doyle, Sarah (2020)Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many ... -
Characterisation of the role of Bruton's tyrosine kinase in toll-like receptor signalling
Doyle, Sarah (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007)Toll-like receptors (TLRs) are the primary surveillance system for the detection of pathogens and are crucial to the activation of the host innate response. TLRs contain an extracellular leucine rich repeat region which ... -
Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14.
O'Neill, Luke; Doyle, Sarah; Canavan, Mary (2013)Polyunsaturated fatty acids (PUFA) can modulate the immune response, however the mechanism by which they exert this effect remains unclear. Previous studies have clearly demonstrated that the cis-9, trans-11 isomer of ... -
Cytosolic dsRNA improves neonatal innate immune responses to adjuvants in use in paediatric vaccines.
Walsh, Patrick; Doyle, Sarah; Brennan, Kiva (2022)Pattern recognition receptors (PRRs) of the innate immune system represent the critical front-line defense against pathogens, and new vaccine formulations target these PRR pathways to boost vaccine responses, through ... -
Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy
Doyle, Sarah; Campbell, Matthew; Humphries, Peter; Hudson, Natalie (2019)Age-related macular degeneration (AMD) is the leading cause of central retinal vision loss worldwide, with an estimated 1 in 10 people over the age of 55 showing early signs of the condition. There are currently no forms ... -
Editorial: IL-1 Family Members in Health and Disease
Doyle, Sarah (2019)In 1985, two distinct cDNAs encoding proteins sharing human Interleukin-1 (IL-1) activity were described, thus defining the first two members of the IL-1 family—IL-1α and IL-1β. These potent pro-inflammatory cytokines have ... -
IL-1 family cytokine regulation of vascular permeability and angiogenesis
Doyle, Sarah; Fahey, Erin (2019)The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals. It has long been established that IL-1 is capable of simultaneously ... -
IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration
Lavelle, Edward; Gardiner, Clair; Campbell, Matthew; Humphries, Peter; Fallon, Padraic; Humphries, Marian; Doyle, Sarah; Brennan, Kiva (2014)Age-related macular degeneration (AMD) is the most common form of central retinal blindness globally. Distinct processes of the innate immune system, specifically activation of the NLRP3 inflammasome, have been shown to ... -
Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis.
Doyle, Sarah; Ward, Mark; Brennan, Kiva (2020)Rationale Mutations in the cystic fibrosis transmembrane regulator (CFTR) gene form the basis of cystic fibrosis (CF). There remains an important knowledge gap in CF as to how diminished CFTR activity leads to the dominant ... -
Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction.
Walsh, Patrick; Doyle, Sarah; Fallon, Padraic (2019)Members of the interleukin-1 (IL-1) family are important mediators of obesity and metabolic disease and have been described to often play opposing roles. Here we report that the interleukin-36 (IL-36) subfamily can play a ... -
Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies
Doyle, Sarah; Little, Mark; Fearon, Ursula; Moran, Barry (2019)Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy. Their significance in ANCA vasculitis (AAV) ... -
Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration
Doyle, Sarah; Campbell, Matthew (2022)As the resident immune cells in the retina, microglia play important homeostatic roles in retinal immune regulation and neuroprotection. However, chronic microglia activation is a common hallmark of many degenerative retinal ... -
SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration
Monaghan, Michael; Doyle, Sarah; Humphries, Peter; Carty, Michael; Bowie, Andrew; Campbell, Matthew; Humphries, Marian (2020)Retinal degeneration is the leading cause of incurable blindness worldwide and is characterised by progressive loss of light-sensing photoreceptors in the neural retina. SARM1 is known for its role in axonal degeneration, ... -
SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration
Doyle, Sarah; Bowie, Andrew; Campbell, Matthew; Greene, Chris (2022)SARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a ... -
Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration.
Doyle, Sarah; Campbell, Matthew; Brennan, Kiva; Greene, Chris (2020)Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction. ...