Browsing by Author "DOYLE, SARAH"
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Bruton's Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin
DOYLE, SARAH; O'NEILL, LUKE; QUINN, SUSAN (2013)B cells signal through both the B cell receptor (BCR) which binds antigens and Toll-like receptors (TLRs) including TLR9 which recognises CpG DNA. Activation of TLR9 synergises with BCR signalling when the BCR and TLR9 ... -
IL-10 inhibits miR-155 induction by Toll-like receptors.
O'NEILL, LUKE; DOYLE, SARAH; MCCOY, CLAIRE; SHEEDY, FREDERICK JOHN; QUINN, SUSAN; SHEEDY, FREDERICK (2010)IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. In this study we have examined whether modulation of micro-RNAs ... -
NLRP3 Inflammasome and Pathobiology in AMD.
DOYLE, SARAH (2015) -
Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15.
DOYLE, SARAH; O'NEILL, LUKE; QUINN, SUSAN (2013)n this study we describe a previously unreported function for NFκB2, an NFκB family transcription factor, in antiviral immunity. NFκB2 is induced in response to poly(I:C), a mimic of viral dsRNA. Poly(I:C), acting via TLR3, ... -
Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives
CAMPBELL, MATTHEW; DOYLE, SARAH (2015)The inflammasome is a molecular platform formed by activation of an innate immune pattern recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC (apoptosis-related speck-like protein ... -
TRAM is required for TLR2 endosomal signaling to type I IFN induction.
BOWIE, ANDREW; DOYLE, SARAH; MCLOUGHLIN, RACHEL (2014)Detection of microbes by TLRs on the plasma membrane leads to the induction of pro-inflammatory cytokines such as TNF-α, via activation of NF-κB. Alternatively, activation of endosomal TLRs leads to the induction of type ...