Browsing by Author "Cunningham, Colm"
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Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium
Cunningham, Colm (2020)Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood and cognition. In vulnerable individuals, acute illness can also ... -
Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice
Cunningham, Colm; Harkin, Andrew (2021)Locus coeruleus (LC)-derived noradrenaline is important in cognition and decreases with age, but the impact of prior noradrenaline deficiency on vulnerability to inflammation-induced acute cognitive dysfunction is ... -
Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1?? drives amplified responses in primed astrocytes and neuronal network dysfunction
Cunningham, Colm; Cunningham, Mark (2021)Neuroinflammation contributes to Alzheimer’s disease (AD) progression. Secondary inflammatory insults trigger delirium and can accelerate cognitive decline. Individual cellular contributors to this vulnerability require ... -
Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms
Cunningham, Colm; Skelly, Donal T.; Griffin, Éadaoin W.; Murray, Carol L.; Harney, Sarah; O'Boyle, Conor; Hennessy, Edel; Dansereau, Marc-Andre; Nazmi, Arshed; Tortorelli, Lucas; Rawlins, J. Nicholas; Bannerman, David M. (2018)Systemic inflammation can impair cognition with relevance to dementia, delirium and post-operative cognitive dysfunction. Episodes of delirium also contribute to rates of long-term cognitive decline, implying that these ... -
Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity
Dunne, Aisling; Cunningham, Colm (2019)Astrocytes are the most numerous cell type in the brain and perform several essential functions in supporting neuronal metabolism and actively participating in neural circuit and behavioral function. They also have ... -
Characterising neuropsychiatric disorders in patients with COVID-19
Cunningham, Colm (2020) -
Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
Lavelle, Edward; Cox, Donal; Cunningham, Colm; Dunne, Aisling (2019)Type I interferons (IFN‐I) are the principal antiviral molecules of the innate immune system and can be made by most cell types, including central nervous system cells. IFN‐I has been implicated in neuroinflammation during ... -
Delirium
Cunningham, Colm (2020)Delirium, a syndrome characterized by an acute change in attention, awareness and cognition, is caused by a medical condition that cannot be better explained by a pre-existing neurocognitive disorder. Multiple predisposing ... -
Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age
Cunningham, Colm; Mitchell, Kevin (2021)Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C is frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative disorders ... -
International drive to illuminate delirium: A developing public health blueprint for action
Cunningham, Colm (2020)Presently, there is a clear societal and demographic imperative to identify and deliver interventions that are effective in reducing dementia. With the high failure rate of compounds in clinical trials, and with ... -
Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss
Cunningham, Colm (2022)Macrophages are abundant in the cochlea; however, their role in hearing loss is not well understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an inflammatory response, which includes ... -
Publisher Correction: Delirium (Nature Reviews Disease Primers, (2020), 6, 1, (90), 10.1038/s41572-020-00223-4)
Cunningham, Colm (2020)Delirium, a syndrome characterized by an acute change in attention, awareness and cognition, is caused by a medical condition that cannot be better explained by a pre-existing neurocognitive disorder. Multiple predisposing ... -
Reactive astrocyte nomenclature, definitions, and future directions
Cunningham, Colm (2021)Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, ... -
A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank
Cunningham, Colm (2020)Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it is particularly common among older adults, and is closely linked with underlying neurocognitive disorders. Evidence is mounting ...