Browsing by Author "Creagh, Emma"

Now showing items 1-8 of 8

    • Autophagy controls IL-1? secretion by targeting pro-IL-1? for degradation 

      Lavelle, Edward; Creagh, Emma (2011)
      Autophagy is a key regulator of cellular homeostasis that can be activated by pathogen-associated molecules and recently has been shown to influence IL-1? secretion by macrophages. However, the mechanisms behind this are ...

    • Caspase-11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis 

      Lavelle, Edward; Creagh, Emma; Munoz-Wolf, Natalia (2019)
      Inflammasomes are multiprotein complexes that respond to infection or injury to activate inflammation. Inflammatory caspases, caspase-1, 4 and 5 in humans, and their murine orthologues caspase-1 and 11 are crucial components ...

    • Caspase-11 promotes allergic airway inflammation 

      Creagh, Emma; Lavelle, Edward; O'Neill, Luke; Mills, Kingston; Zasłona, Zbigniew; Flis, Ewelina; Wilk, Mieszko M.; Carroll, Richard G.; Palsson-McDermott, Eva M.; Hughes, Mark M.; Diskin, Ciana; Banahan, Kathy; Ryan, Dylan G.; Hooftman, Alexander; Misiak, Alicja; Kearney, Jay; Lochnit, Gunter; Bertrams, Wilhelm; Greulich, Timm; Schmeck, Bernd; McElvaney, Oliver J.; Wygrecka, Małgorzata (2020)
      Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 ...

    • Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis 

      Creagh, Emma; Mills, Kingston; Flood, Brie; Manils, Joan; Nulty, Ciara; Flis, Ewelina; Kenealy, Sinead; Barber, Gillian; Fay, Joanna; Kay, Elaine (2019)
      Murine inflammatory caspase-11 has an important role in intestinal epithelial inflammation and barrier function. Activation of the non-canonical inflammasome, mediated by caspase-11, serves as a regulatory pathway for the ...

    • Characterizing caspase-1 involvement during esophageal disease progression. 

      Creagh, Emma; O'Sullivan, Jacintha; Reynolds, John; Ravi, Narayanasamy (2020)
      Barrett’s esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation ...

    • Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense 

      Creagh, Emma (2019)
      The mammalian innate immune system deals with invading pathogens and stress by activating pattern-recognition receptors (PRRs) in the host. Initially proposed to be triggered by the discrimination of defined molecular ...

    • Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation 

      Dunne, Aisling; Fletcher, Jean; Creagh, Emma; Basdeo, Sharee (2016)
      The main limitation to successful transplantation is the antigraft response developed by the recipient immune system, and the adverse side effects of immunosuppressive agents which are associated with significant toxicity ...

    • Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. 

      O'Neill, Luke; Lavelle, Edward; Creagh, Emma (2009)
      Many currently used and candidate vaccine adjuvants are particulate in nature, but their mechanism of action is not well understood. Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) ...