Browsing by Author "Coleman, David"
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A population structure analysis of Candida dubliniensis using multilocus sequence typing and an investigation of the molecular mechanism(s) of clade-specific resistance to 5-fluorocytosine
McManus, Brenda (Trinity College (Dublin, Ireland). School of Dental Science, 2009)Candida dubliniensis shares many phenotypic and genetic characteristics with its closest relative, Candida albicans, which most likely delayed the identification and subsequent classification of C. dubliniensis as a distinct ... -
An investigation into the biofilm-associated bacterial contamination of dental chair units and dental unit output water supplies and its control
Tuttlebee, Claire M. (Trinity College (Dublin, Ireland). School of Dental Science, 2005)Many modern medical devices, including dental chair units (DCUs), are potential reservoirs of infection as they can harbour biofilm-associated microorganisms. This study investigated several aspects of DCUs related to ... -
An investigation into the molecular epidemiology of Candida dubliniensis
Gee, Sarah F. (Trinity College (Dublin, Ireland). School of Dental Science, 2002)Candida dubliniensis is a recently described Candida species primarily associated with oral candidosis in Human Immunodeficiency Virus (HlV)-infected and AIDS patients. The population structure of C. dubliniensis was ... -
An investigation into the relative adhesion of Candida dubliniensis and Candida albicans to human cells and extracellular matrix proteins
Jordan, Rachael P. C. (Trinity College (Dublin, Ireland). School of Dental Science, 2009)Candida dubliniensis is a germ tube-positive, chlamydospore-producing yeast species originally recovered from the oral cavities of HIV-infected individuals and AIDS patients and first described in 1995. It is closely related ... -
AZOLE SUSCEPTIBILITY AND RESISTANCE IN CANDIDA DUBLINIENSIS
Sullivan, Derek; Coleman, David; Moran, Gary (2005)Candida dubliniensis is a recently described species of pathogenic yeast that shares many phenotypic features with Candida albicans. It is primarily associated with oral colonization and infection in HIV-infected individuals. ... -
Characterisation of Candida albicans populations associated with chronic hyperplastic candidosis (Candida leukoplakia) and non-Candida leukoplakia lesions in patients presenting with oral leukoplakic lesions in Ireland
Abdulrahim, Mohammed H. (Trinity College (Dublin, Ireland). School of Dental Science, 2011)Oral squamous cell carcinoma is a significant global health problem, affecting about a half of a million people worldwide annually. Oral leukoplakic lesions have been reported to have significantly increased potential for ... -
Characterisation of genotypic and phenotypic differences between Candida dubliniensis and Candida albicans
Donnelly, Samantha (Trinity College (Dublin, Ireland). Department of Microbiology, 2001)Summary -Candida dubliniensis is a recently described Candida species associated with oral candidosis in Human Immunodeficiency Virus (HIV)-infected and AIDS patients. The phylogenetic position of C. dubliniensis has ... -
Comparative genetic analysis of nosocomial methicillin-resistant Staphylococcus aureus populations in Ireland 1971-2004
Shore, Anna (Trinity College (Dublin, Ireland). School of Dental Science, 2005)Methicillin-resistant Staphylococcus aureus (MRSA) is the most prevalent pathogen responsible for nosocomial infections worldwide and Ireland has one of the highest rates of nosocomial MRSA infections in Europe. In the ... -
Comparative growth analysis of Candida dubliniensis and Candida albicans in vitro and in selected infection models
Stokes, Cheryl (Trinity College (Dublin, Ireland). School of Dental Science, 2006)Candida dubliniensis is the species most closely related to C. albicans and is primarily associated with colonisation and oral candidiasis in Human Immunodeficiency Virus (HlV)-infected individuals and AIDS patients. Despite ... -
COMPARATIVE TRANSCRIPT PROFILING OF Candida albicans AND Candida dubliniensis IDENTIFIES SFL2, A C. albicans GENE REQUIRED FOR VIRULENCE IN A RECONSTITUTED EPITHELIAL INFECTION MODEL
Sullivan, Derek; Coleman, David; Moran, Gary (2010)Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. ... -
Comprehensive molecular characterisation of endemic and sporadic methicillin resistant Staphylococcus aureus recovered in Irish hospitals
Kinnevey, Peter (Trinity College (Dublin, Ireland). School of Dental Science, 2011)Methicillin-resistant Staphylococcus aureus (MRSA) is a prevalent pathogen responsible for hospital- and community-acquired infections worldwide. Molecular typing of Irish MRSA isolates has revealed that different MRSA ... -
Contribution of whole-genome sequencing to understanding of the epidemiology and control of meticillin-resistant Staphylococcus aureus
Coleman, David; Humphreys, Hilary (2019)In recent years, approaches to tracking the spread of meticillin-resistant Staphylococcus aureus (MRSA) as part of outbreak management have used conventional DNA-based methods, including pulsed-field gel electrophoresis ... -
Development of differential media for Candida dubliniensis and identification of a novel clade of Candida dubliniensis predominant in the Middle East
Al Mosaid, Asmaa (Trinity College (Dublin, Ireland). School of Dental Science, 2005)Candida dubliniensis is a newly described Candida species originally associated with oral colonisation and candidosis in Human Immunodeficiency Virus (HlV)-infected, and acquired immunodeficiency syndrome (AIDS) patients. ... -
Development of long-term practical solutions to the universal problem of biofilm contamination of dental unit waterlines
O'Donnell, Mary J. (Trinity College (Dublin, Ireland). School of Dental Science, 2009)Microbial contamination of dental chair unit (DCU) output water by biofilm growth in dental unit waterlines (DUWLs) is a universal problem and a potentially significant source of cross-infection. At the outset of this ... -
EFFECTIVE CLEANING AND DECONTAMINATION OF THE INTERNAL AIR AND WATER CHANNELS, HEADS AND HEAD-GEARS OF MULTIPLE CONTRA ANGLE DENTAL HANDPIECES USING AN ENZYMATIC DETERGENT AND AUTOMATED WASHER DISINFECTION IN A DENTAL HOSPITAL SETTING
Coleman, David; Deasy, Emily; O'Donnell, Mary (2022)Background Dental handpieces (DHPs) are reusable invasive medical devices that must be cleaned, decontaminated, lubricated and steam sterilized after use. DHPs have a complex internal design including narrow channels, ... -
ELIMINATION OF BIOFILM AND MICROBIAL CONTAMINATION RESERVOIRS IN HOSPITAL WASHBASIN U-BENDS BY AUTOMATED CLEANING AND DISINFECTION WITH ELECTROCHEMICALLY ACTIVATED SOLUTIONS
Coleman, David; O'Donnell, Mary; Deasy, Emily; Russell, Ronald (2016) -
AN EMERGING PANTON-VALENTINE (PVL)-POSITIVE CC5-METICILLIN-RESISTANT Staphylococcus aureus-IVc CLONE RECEOVERED FROM HOSPITAL AND COMMUNITY SETTINGS OVER A 17-YEAR PERIOD FROM 12 COUNTRIES INVESTIGATED BY WHOLE-GENOME SEQUENCING
Coleman, David; Kinnevey, Peter (2023)Background A novel Panton–Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) clonal complex (CC)5-MRSA-IVc (‘Sri Lankan’ clone) was recently described from Sri Lanka. Similar isolates ... -
FIRST DESCRIPTION OF ARGININE CATABOLIC MOVILE ELEMENT (ACME) TYPE VI HARBORING THE kdp OPERON ONLY IN Staphylococcus epidermidis USING SHORT AND LONG READ WHOLE GENOME SEQUENCING: FURTHER EVIDENCE OF ACME DIVERSITY
Coleman, David; Mc Manus, Brenda (2019)The arginine catabolic mobile element (ACME) was first described in methicillin-resistant Staphylococcus aureus and is considered to enhance transmission, persistence and survival. Subsequently ACMEs were shown to be more ... -
Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress
Enjalbert, Brice; Moran, Gary; Vaughan, Claire; Yeomans, Tim; MacCallum, Donna; Quinn, Janet; Coleman, David; Brown, Alistair; SULLIVAN, DEREK (Wiley-Blackwell, 2009)Candida albicans is more pathogenic than Candida dubliniensis. However, this disparity in virulence is surprising given the high level of sequence conservation and the wide range of phenotypic traits shared by these two ...