Browsing by Author "Cloonan, Suzanne"
Now showing items 1-14 of 14
-
Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease
Cloonan, Suzanne (2020)Metabolic plasticity involving shifts between mitochondrial respiration and glycolysis is emerging as a crucial component of innate immune cell function. The number of alveolar macrophages (AMs), the most abundant ... -
Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort
Cloonan, Suzanne (2021)Background: There is a lack of mechanism-driven, clinically relevant biomarkers in chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction, a proposed disease mechanism in COPD, is associated with the release ... -
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort
Cloonan, Suzanne (2020)BACKGROUND: Mitochondrial dysfunction, a proposed mechanism of chronic obstructive pulmonary disease (COPD) pathogenesis, is associated with the leakage of mitochondrial DNA (mtDNA), which may be detected extracellularly ... -
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing
Cloonan, Suzanne (2020)Bleeding and altered iron distribution occur in multiple gastrointestinal diseases, but theimportance and regulation of these changes remain unclear. We found that hepcidin, themaster regulator of systemic iron homeostasis, ... -
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity
Cloonan, Suzanne (2019)The prevalence of obesity is rising worldwide, and obese patients constitute a specific population in the intensive care unit. Acute respiratory distress syndrome (ARDS) incidence is increased in obese patients. Exposure ... -
Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS
Cloonan, Suzanne (2020)Levels of iron and iron-related proteins including ferritin are higher in the lung tissue and lavage fluid of individuals with chronic obstructive pulmonary disease (COPD), when compared to healthy controls. Whether more ... -
Inflammation drives alternative first exon usage to regulate immune genes including a novel iron regulated isoform of Aim2
Cloonan, Suzanne (2021)Determining the layers of gene regulation within the innate immune response is critical to our understanding of the cellular responses to infection and dysregulation in disease. We identified a conserved mechanism of gene ... -
Mitochondrial Iron in Human Health and Disease
Cloonan, Suzanne (2019)Mitochondria are an iconic distinguishing feature of eukaryotic cells. Mitochondria encompass an active organellar network that fuses, divides, and directs a myriad of vital biological functions, including energy metabolism, ... -
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
Cloonan, Suzanne (2019)Accumulating evidence illustrates a fundamental role for mitochondria in lung alveolar type 2 epithelial cell (AEC2) dysfunction in the pathogenesis of idiopathic pulmonary fibrosis. However, the role of mitochondrial ... -
Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease
Cloonan, Suzanne (2021)Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading microorganisms. As one of the most conserved activities of the innate ... -
Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages
Cloonan, Suzanne; O'Neill, Luke (2022)Activated macrophages undergo metabolic reprogramming, which not only supports their energetic demands but also allows for the production of specific metabolites that function as signaling molecules. Several Krebs cycles, ... -
To "Fe"ed or Not to "Fe"ed: Iron Depletion Exacerbates Emphysema Development in Murine Smoke Model
Cloonan, Suzanne (2020) -
ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients
Cloonan, Suzanne (2019)Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease that is currently the third leading cause of death worldwide. Recent reports have indicated that dysfunctional iron handling in the lungs of COPD ...