Browsing by Author "COSTELLO, DEREK"
Now showing items 1-7 of 7
-
Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
(2012)Objective: Diabetes mellitus is associated with cognitive deficits and an increased risk of dementia, particularly in the elderly. These deficits and the corresponding neurophysiological structural and functional alterations ... -
Dok2 mediates the CD200Fc attenuation of Aß-induced changes in glia.
(2012)Background: The interaction between the membrane glycoprotein, CD200 and its cognate receptor CD200 receptor (CD200R), has been shown to play a role in maintaining microglia in a quiescent state. There is evidence of ... -
IL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice
(2011)Single-Ig-interleukin-1 related receptor (SIGIRR) is a member of the interleukin (IL)-1/Toll-like receptor (TLR) family. It negatively regulates inflammation, rendering SIGIRR-/- mice more susceptible to inflammatory ... -
Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation.
(2011)The membrane glycoprotein CD200 is expressed on several cell types including neurons whereas expression of its receptor, CD200R, is restricted principally to cells of the myeloid lineage, including microglia. The interaction ... -
SIGIRR modulates the inflammatory response in the brain
(Elsevier, 2010)One of the more recently described members of the interleukin-1 (IL-1) receptor family, single-Ig-Interleukin-1 related receptor (SIGIRR), has been identified as a negative regulator of inflammation in several tissues. ... -
Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β
(2013)The family of toll-like receptors (TLR) plays a major role in innate immunity due to their pathogen-recognition abilities. TLR3 is a sensor for double-stranded RNA, and regulates host-defense responses to several viruses, ...
