Browsing by Author "CORVIN, AIDEN"
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Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.
QUINN, EMMA; KENNY, ELAINE; CORVIN, AIDEN; GILL, MICHAEL; MORRIS, DEREK (2010)Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases, such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes with specific brain functions. Under these ... -
Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
CORVIN, AIDEN; DONOHOE, GARY (2014)Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such ... -
Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample.
MORRIS, DEREK; BRADLEY, DANIEL; DONOHOE, GARY; GILL, MICHAEL; CORVIN, AIDEN; FAHEY, CIARA; HARDIMAN, ORLA; MCLAUGHLIN, RUSSELL (2014)The hexonucleotide repeat expansion 'GGGGCC' at the C9ORF72 gene has been strongly linked with amyotrophic lateral sclerosis and frontotemporal dementia. There is some evidence for clinical and genetic overlap between ... -
An assessment of the Irish population for large-scale genetic mapping studies involving epilepsy and other complex diseases
CORVIN, AIDEN; GILL, MICHAEL; MORRIS, DEREK WILLIAMS; O'DUSHLAINE, COLM (Nature Publishing Group, 2008)The recent completion of the International HapMap Project has rapidly advanced our understanding of linkage disequilibrium (LD) in the human genome. Today, tagging SNPs (tSNPs) can be quickly and easily selected and ... -
Bipolar affective puerperal psychosis- genome-wide significant evidence for linkage to chromosome 16.
CORVIN, AIDEN; GILL, MICHAEL (American Psychiatric Publishing, 2007)OBJECTIVE: Vulnerability to the triggering of bipolar episodes by childbirth aggregates in families and may define a genetically relevant subtype of bipolar disorder. The authors conducted a search by systematic whole ... -
Clinical symptomatology and the psychosis risk gene, ZNF804A
CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK; GILL, MICHAEL (2010)The single nucleotide polymorphism (SNP) rs1344706, mapping to the gene ZNF804A, has been implicated in schizophrenia susceptibility ([O'Donovan et al., 2008], [International Schizophrenia Consortium, 2009], [Stefansson ... -
CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1.
CORVIN, AIDEN; MORRIS, DEREK; GILL, MICHAEL (2014) -
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
CORVIN, AIDEN; GILL, MICHAEL; MORRIS, DEREK WILLIAMS (Nature Publishing Group, 2008)To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also ... -
Common variant at 16p11.2 conferring risk of psychosis
CORVIN, AIDEN (2014) -
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
CORVIN, AIDEN (2012)We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide association study data with other genetic and ... -
The correlation between reading and mathematics ability at age twelve has a substantial genetic component
CORVIN, AIDEN (2014)Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to ... -
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
CORVIN, AIDEN (2018)Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. ... -
Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing.
HARDIMAN, ORLA; CORVIN, AIDEN; MORRIS, DEREK; MCLAUGHLIN, RUSSELL; KENNY, ELAINE (2013) -
Duplications in RB1CC1 are associated with schizophrenia; identification in large European sample sets
CORVIN, AIDEN (Nature Publishing Group, 2013)Schizophrenia (SCZ) is a severe and debilitating neuropsychiatric disorder with an estimated heritability of ~80%. Recently, de novo mutations, identified by next-generation sequencing (NGS) technology, have been suggested ... -
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2011)Rare copy number variants (CNVs) play a prominent role in the etiology of schizophrenia and other neuropsychiatric disorders 1 . Substantial risk for schizophrenia is conferred by large (>500 kb) CNVs at several loci, ... -
Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia
ROBERTSON, IAN; GILL, MICHAEL; MORRIS, DEREK; GARAVAN, HUGH; CORVIN, AIDEN; FOXE, JOHN (2008)Background: Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. ... -
Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style.
MORRIS, DEREK; DONOHOE, GARY; HARGREAVES, APRIL; GILL, MICHAEL; FAHEY, CIARA; CORVIN, AIDEN; TROPEA, DANIELA (2014)BACKGROUND: A single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2) gene was recently identified as a common risk variant for schizophrenia. The mechanism by which CNNM2 confers risk is unknown. AIMS: To ... -
Effects of MIR137 on fronto-amygdala functional connectivity.
FAHEY, CIARA; MORRIS, DEREK; KELLY, SINEAD; GILL, MICHAEL; DONOHOE, GARY; REILLY, RICHARD; CORVIN, AIDEN (2014)MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with ... -
Effects of ZNF804A on auditory P300 response in schizophrenia.
GILL, MICHAEL; CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK; TROPEA, DANIELA (2014) -
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood
CORVIN, AIDEN; DONOHOE, GARY; GILL, MICHAEL (Elsevier (Cell Press), 2018)Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score ...