Browsing by Author "CORVIN, AIDEN"
Now showing items 1-20 of 73
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Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.
QUINN, EMMA; KENNY, ELAINE; CORVIN, AIDEN; GILL, MICHAEL; MORRIS, DEREK (2010)Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases, such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes with specific brain functions. Under these ... -
Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
CORVIN, AIDEN; DONOHOE, GARY (2014)Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such ... -
Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample.
MORRIS, DEREK; BRADLEY, DANIEL; DONOHOE, GARY; GILL, MICHAEL; CORVIN, AIDEN; FAHEY, CIARA; HARDIMAN, ORLA; MCLAUGHLIN, RUSSELL (2014)The hexonucleotide repeat expansion 'GGGGCC' at the C9ORF72 gene has been strongly linked with amyotrophic lateral sclerosis and frontotemporal dementia. There is some evidence for clinical and genetic overlap between ... -
An assessment of the Irish population for large-scale genetic mapping studies involving epilepsy and other complex diseases
CORVIN, AIDEN; GILL, MICHAEL; MORRIS, DEREK WILLIAMS; O'DUSHLAINE, COLM (Nature Publishing Group, 2008)The recent completion of the International HapMap Project has rapidly advanced our understanding of linkage disequilibrium (LD) in the human genome. Today, tagging SNPs (tSNPs) can be quickly and easily selected and ... -
Common variant at 16p11.2 conferring risk of psychosis
CORVIN, AIDEN (2014) -
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
CORVIN, AIDEN (2012)We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide association study data with other genetic and ... -
The correlation between reading and mathematics ability at age twelve has a substantial genetic component
CORVIN, AIDEN (2014)Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy. Here we show, using twin and genome-wide analysis, that there is a substantial genetic component to ... -
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
CORVIN, AIDEN (2018)Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. ... -
Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing.
HARDIMAN, ORLA; CORVIN, AIDEN; MORRIS, DEREK; MCLAUGHLIN, RUSSELL; KENNY, ELAINE (2013) -
Duplications in RB1CC1 are associated with schizophrenia; identification in large European sample sets
CORVIN, AIDEN (Nature Publishing Group, 2013)Schizophrenia (SCZ) is a severe and debilitating neuropsychiatric disorder with an estimated heritability of ~80%. Recently, de novo mutations, identified by next-generation sequencing (NGS) technology, have been suggested ... -
Effects of MIR137 on fronto-amygdala functional connectivity.
FAHEY, CIARA; MORRIS, DEREK; KELLY, SINEAD; GILL, MICHAEL; DONOHOE, GARY; REILLY, RICHARD; CORVIN, AIDEN (2014)MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with ... -
Effects of ZNF804A on auditory P300 response in schizophrenia.
GILL, MICHAEL; CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK; TROPEA, DANIELA (2014) -
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood
CORVIN, AIDEN; DONOHOE, GARY; GILL, MICHAEL (Elsevier (Cell Press), 2018)Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score ...