Browsing by Author "CORR, SINEAD"
Now showing items 1-6 of 6
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Both TLR2 and TRIF contribute to interferon-? production during Listeria infection.
O'NEILL, LUKE; CORR, SINEAD (2012)Synthesis of interferon-? (IFN-?) is an innate response to cytoplasmic infection with bacterial pathogens. Our recent studies showed that Listeria monocytogenes limits immune detection and IFN-? synthesis via deacetylation ... -
Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation
O'NEILL, LUKE; QUINN, SUSAN; BOURKE, NOLLAIG; CORR, SINEAD (2014)The apoptosis-associated speck-like protein containing a caspase-activating recruitment domain (ASC) is an essential component of several inflammasomes, multiprotein complexes that regulate caspase-1 activation and ... -
Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha
MCGETTRICK-DILLON, ANNE; CORR, SINEAD; PALSSON, EVA; KELLY, VINCENT; O'NEILL, LUKE (2013)Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis with 2-deoxyglucose ... -
TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia.
O'LEARY, JOHN; MARTIN, CARA; O'NEILL, LUKE; DOYLE, BRENDAN; ABRAHAMSON, DAVID; CORR, SINEAD; CARPENTER, SUSAN (2012)