Browsing by Author "Basdeo, Sharee"
Now showing items 1-7 of 7
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Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis
Phelan, James; Keane, Joseph; Basdeo, Sharee; O'Sullivan, Mary; O'Neill, Luke (2020)Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis ... -
The Effects of Trained Innate Immunity on T Cell Responses; Clinical Implications and Knowledge Gaps for Future Research
Mills, Kingston; Basdeo, Sharee (2021)The burgeoning field of innate immune training, also called trained immunity, has given immunologists new insights into the role of innate responses in protection against infection and in modulating inflammation. Moreover, ... -
Inhibiting Histone Deacetylases in Human Macrophages Promotes Glycolysis, IL-1β, and T Helper Cell Responses to Mycobacterium tuberculosis
Phelan, James; Keane, Joseph; Basdeo, Sharee (2020)Tuberculosis (TB) is the leading infectious killer in the world. Mycobacterium tuberculosis (Mtb), the bacteria that causes the disease, is phagocytosed by alveolar macrophages (AM) and infiltrating monocyte-derived ... -
Modulating Iron for Metabolic Support of TB Host Defense
Phelan, James; Keane, Joseph; Basdeo, Sharee (2018)Tuberculosis (TB) is the world's biggest infectious disease killer. The increasing prevalence of multidrug-resistant and extensively drug-resistant TB demonstrates that current treatments are inadequate and there is an ... -
Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation
Dunne, Aisling; Fletcher, Jean; Creagh, Emma; Basdeo, Sharee (2016)The main limitation to successful transplantation is the antigraft response developed by the recipient immune system, and the adverse side effects of immunosuppressive agents which are associated with significant toxicity ...