Browsing by Author "BUCKLEY, CONOR"
Now showing items 1-16 of 16
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Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation.
BUCKLEY, CONOR; VINARDELL, TATIANA; KELLY, DANIEL (2014)Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) can be leveraged to generate bone in vivo by executing an endochondral program, leading to increased interest in the use of such hypertrophic grafts ... -
Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure
STEWARD, ANDREW; KELLY, DANIEL; THORPE, STEPHEN; BUCKLEY, CONOR (2012)Both hydrostatic pressure (HP) and cell-matrix interactions have independently been shown to regulate the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to test the hypothesis ... -
A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes.
KELLY, DANIEL; BUCKLEY, CONOR (2014)Despite an increased interest in the use of hydrogel encapsulation and cellular self-assembly (often termed "self-aggregating" or "scaffold-free" approaches) for tissue-engineering applications, to the best of our knowledge, ... -
Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad
KELLY, DANIEL; BUCKLEY, CONOR; VINARDELL, TATIANA (2011)The objective of this study was to determine the functional properties of cartilaginous tissues generated by porcine MSCs isolated from different tissue sources, and to compare these properties to those derived from ... -
Coupling freshly isolated CD44+ infrapatellar fat pad derived stromal cells with a tgf-β3 eluting cartilage ecm-derived scaffold as a single stage strategy for promoting chondrogenesis.
KELLY, DANIEL; VINARDELL, TATIANA; BUCKLEY, CONOR (2015) -
Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad.
BUCKLEY, CONOR; KELLY, DANIEL (2014)The objective of this study was to investigate how joint specific biomechanical loading influences the functional development and phenotypic stability of cartilage grafts engineered in vitro using stem/progenitor cells ... -
Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration
KELLY, DANIEL; BUCKLEY, CONOR; O'BRIEN, FERGAL; CUNNIFFE, GRÁINNE (2016) -
Infrapatellar Fat Pad-Derived Stem Cells Maintain Their Chondrogenic Capacity in Disease and Can be Used to Engineer Cartilaginous Grafts of Clinically Relevant Dimensions.
KELLY, DANIEL; BUCKLEY, CONOR (2014)A therapy for regenerating large cartilaginous lesions within the articular surface of osteoarthritic joints remains elusive. While tissue engineering strategies such as matrix-assisted autologous chondrocyte implantation ... -
Intrinsic multipotential mesenchymal stromal cell activity in gelatinous Heberden's nodes in osteoarthritis at clinical presentation.
BUCKLEY, CONOR (2014)Introduction Gelatinous Heberden’s nodes (HNs), also termed synovial cysts, are a common form of generalized osteoarthritis (OA). We sought to determine whether HN cases at clinical presentation contained multipotential ... -
Surface Finish in Micro-drilling of PTFE
KELLY, KEVIN; O'DONNELL, GARRET; BUCKLEY, CONOR (2008)Surface finish of engineering components pl ays a key role in their functionality, particularly where the size of the geometric feat ures of the component decreases. This paper reports on such an application – the ... -
Tissue engineering scaled-up, anatomically shaped osteochondral constructs for joint resurfacing
KELLY, DANIEL; BUCKLEY, CONOR; VINARDELL, TATIANA (2015)Arthroplasty is currently the only surgical procedure available to restore joint function following articular cartilage and bone degeneration associated with diseases such as osteoarthritis (OA). A potential alternative ... -
Tissue engineering whole bones through endochondral ossification: Regenerating the distal phalanx
BUCKLEY, CONOR; KELLY, DANIEL (2015)Novel strategies are urgently required to facilitate regeneration of entire bones lost due to trauma or disease. In this study, we present a novel framework for the regeneration of whole bones by tissue engineering ...