Browsing by Author "Ahearne, Mark"
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Characterization of extracellular matrix modified poly(¿-caprolactone) electrospun scaffolds with differing fiber orientations for corneal stroma regeneration
Ahearne, Mark (2020)Alternatives to donor cornea transplantation based on tissue engineering are desirable to overcome the current severe donor tissue shortage. Many natural polymers have good biological properties but poor mechanical properties ... -
Combined influence of basal media and fibroblast growth factor on the expansion and differentiation capabilities of adipose-derived stem cells.
Ahearne, Mark; Lysaght, Joanne (2014)BACKGROUND: Interest in adipose-derived stem cells (ASCs) has increased in recent years due to their multi-linage differentiation capabilities. While much work has been done to optimize the differentiation media, few ... -
Combining freshly isolated chondroprogenitor cells from the infrapatellar fat pad with a growth factor delivery hydrogel as a putative single stage therapy for articular cartilage repair
Ahearne, Mark; Kelly, Daniel (2014)Growth factor delivery systems incorporating chondroprogenitor cells are an attractive potential treatment option for damaged cartilage. The rapid isolation, processing, and implantation of therapeutically relevant numbers ... -
Decellularization and recellularization of cornea: Progress towards a donor alternative.
Ahearne, Mark (2020)The global shortage of donor corneas for transplantation has led to corneal bioengineering being investigated as a method to generate transplantable tissues. Decellularized corneas are among the most promising materials ... -
Designing Scaffolds for Corneal Regeneration
Ahearne, Mark (2020)Corneal blindness is one of the most common causes of vision loss worldwide, affecting millions of people. To treat these patients, researchers have been examining different approaches to engineer corneal scaffolds suitable ... -
Dextran Preserves Native Corneal Structure During Decellularization.
Ahearne, Mark (2016)Corneal decellularization has become an increasingly popular technique for generating scaffolds for corneal regeneration. Most decellularization procedures result in tissue swelling, thus limiting their application. Here, ... -
The Effect of Calcium and Glucose Concentration on Corneal Epithelial Cell Lines Differentiation, Proliferation, and Focal Adhesion Expression.
Ahearne, Mark (2019)It is known that culture media composition can affect cell behavior, morphology, and gene expression. However,in the case of corneal epithelial cells, the combined role of calcium and glucose concentration in media has not ... -
The effect of prior long-term recellularization with keratocytes of decellularized porcine corneas implanted in a rabbit anterior lamellar keratoplasty model.
Ahearne, Mark (2021)Decellularized porcine corneal scaffolds are a potential alternative to human cornea for keratoplasty. Although clinical trials have reported promising results, there can be corneal haze or scar tissue. Here, we examined ... -
Effect of substrate topography on the regulation of human corneal stromal cells.
Ahearne, Mark (2020)Optimal functionality of native corneal stroma depends on a well-ordered arrangement of extracellular matrix (ECM). To develop an in vitro corneal model, replication of the corneal in vivo microenvironment is needed. In ... -
Engineering a Corneal Stromal Equivalent Using a Novel Multilayered Fabrication Assembly Technique.
Ahearne, Mark (2020)To overcome the serious shortage of donor corneas for transplantation, alternatives based on tissue engineering need to be developed. Decellularized corneas are one potential alternative, but their densely packed collagen ... -
Fabrication and biocompatibility of electroconductive silk fibroin/pedot: Pss composites for corneal epithelial regeneration
Ahearne, Mark (2020)The aim of this study was to develop matrices that can support human corneal epithelial cells and innervation by incorporating a conducting polymer, poly(3,4-ethylenedioxythiophene) poly(styrene sulfonate) (PEDOT:PSS), ... -
Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells.
Buckley, Conor; Kelly, Daniel; Ahearne, Mark; Rolfe, Rebecca (2012)Hydrostatic pressure (HP) is a key component of the in vivo joint environment and has been shown to enhance chondrogenesis of stem cells. The objective of this study was to investigate the interaction between HP and ... -
The impact of decellularization methods on extracellular matrix derived hydrogels.
Ahearne, Mark (2019)Tissue-derived decellularized biomaterials are ideal for tissue engineering applications as they mimic the biochemical composition of the native tissue. These materials can be used as hydrogels for cell encapsulation and ... -
Influence of Biochemical Cues in Human Corneal Stromal Cell Phenotype.
Ahearne, Mark (2019) -
Influence of micropatterned substrates on keratocyte phenotype
Ahearne, Mark (2020)Substrate topographic patterning is a powerful tool that can be used to manipulate cell shape and orientation. To gain a better understanding of the relationship between surface topography and keratocyte behavior, surface ... -
Influence of polydimethylsiloxane substrate stiffness on corneal epithelial cells
Ahearne, Mark (2019)Many cell types are known to modulate their behaviour in response to changes in material stiffness; however, little is known about how stiffness affects corneal epithelial cells. This study aims to investigate the response ... -
Mechanobiology of the corneal epithelium.
Ahearne, Mark (2018) -
An overview of current techniques for ocular toxicity testing.
Ahearne, Mark (2015)Abstract Given the hazardous nature of many materials and substances, ocular toxicity testing is required to evaluate the dangers associated with these substances after their exposure to the eye. Historically, animal tests ... -
Potential for combined delivery of riboflavin and all-trans retinoic acid, from silk fibroin for corneal bioengineering.
Ahearne, Mark (2019)Millions of people worldwide suffer from vision impairing conditions resulting from corneal injury or disease. Silk fibroin (SF) is an emerging biopolymer that has been used for several applications including the fabrication ... -
Retinoic Acid Enhances the Differentiation of Adipose-Derived Stem Cells to Keratocytes In Vitro.
Ahearne, Mark (2017)Purpose: All-trans retinoic acid (RA) supplementation was investigated as a method of enhancing the differentiation of human adipose-derived stem cells (ASCs) to corneal keratocytes in vitro, in combination with a chemically ...