Browsing by Author "ANWYL, ROGER"
Now showing items 1-8 of 8
-
Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide
ANWYL, ROGER; ROWAN, MICHAEL (2004)The mechanisms underlying the inhibition of long-term potentiation (LTP) induction by amyloid -peptide (A ) were investigated in the medial perforant path of the rat and mouse dentate gyrus in vitro . Evidence ... -
Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption.
ANWYL, ROGER (2013)Previous studies indicate that memantine, a low-affinity N-methyl-D-aspartate receptor antagonist, exerted acute protective effects against amyloid-β protein-induced neurotoxicity. In the present study, the chronic effects ... -
Protection against ß-amyloid-induced synaptic and memory impairments via altering ß-amyloid assembly by bis(heptyl)-cognitin
ROWAN, MICHAEL; ANWYL, ROGER; ROWAN, MICHAEL JOSEPH; ANWYL, ROGER (2015)β-amyloid (Aβ) oligomers have been closely implicated in the pathogenesis of Alzheimer’s disease (AD). We found, for the first time, that bis(heptyl)-cognitin, a novel dimeric acetylcholinesterase (AChE) inhibitor derived ...