Browsing by Author "AMU, SYLVIE"
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Activation of human invariant natural killer T cells with a thioglycoside analogue of ?-galactosylceramide
O'FARRELLY, CLIONA; O'REILLY, VINCENT; Dunne, Margaret; AMU, SYLVIE; FALLON, PADRAIC; DOHERTY, DEREK; ZENG, SHIJUAN GRACE (2011)Activation of CD1d-restricted invariant NKT (iNKT) cells with the glycolipid ?-galactosylceramide (?-GalCer) confers protection against disease in murine models, however, clinical trials in humans have had limited impact. ... -
Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells
FALLON, PADRAIC; HAMS, EMILY; AMU, SYLVIE (2011)T follicular helper (TFH) cells are critical initiators in the development of T cell-dependent humoral immunity and the generation of protective immunity. We demonstrate that TFH cell accumulation and Ab production are ... -
Phenotype and Function of CD25-Expressing B Lymphocytes Isolated from Human Umbilical Cord Blood
AMU, SYLVIE (2011)Background. We have shown that approximately 30% of human peripheral blood B-cells express CD25. B cells expressing CD25 display a mature phenotype belonging to the memory B-cell population and have a better proliferative ... -
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.
FALLON, PADRAIC; SAUNDERS, SEAN; AMU, SYLVIE; ATZBERGER, ANN (2010)BACKGROUND: Parasitic helminth infections of humans have been shown to suppress the immune response to allergens. Experimentally, infection of mice with the helminth Schistosoma mansoni prevents allergic airway inflammation ... -
A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins
O'NEILL, LUKE; AMU, SYLVIE; MCCOY, CLAIRE; MORTON, CHARLES; ROGERS, THOMAS; FALLON, PADRAIC; KELLEHER, DERMOT (2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ... -
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
FALLON, PADRAIC; AMU, SYLVIE; SAUNDERS, SEAN; NEL, HENDRIK (2011)The incidence of allergy and asthma in developed countries is on the increase and this trend looks likely to continue. CD4+ T helper 2 (Th2) cells are major drivers of these diseases and their commitment is controlled by ...