Browsing by Author "SULLIVAN, DEREK"
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AIR AND SURFACE CONTAMINATION PATTERNS OF METHICILLIN-RESISTANT Staphylococcus aureus ON EIGHT ACUTE HOSPITAL WARDS
CREAMER, EILISH; SHORE, ANNA; DEASY, EMILY; GALVIN, SANDRA; DOLAN, ANTHONY; WALLEY, NIAMH; McHUGH, SEAMUS; FITZGERALD-HUGHES, DEIRDRE; SULLIVAN, DEREK; CUNNEY, ROBERT; COLEMAN, DAVID C; HUMPHREYS, HILARY (2014-03)BACKGROUND. Methicillin-resistant Staphylococcus aureus (MRSA) can be recovered from hospital air and from environmental surfaces. This poses a potential risk of transmission to patients. OBJECTIVE. To investigate ... -
AVIAN-ASSOCIATED AND HUMAN ISOLATES OF Candida dubliniensis ARE GENETICALLY DISTINCT
SULLIVAN, DEREK; MC MANUS, BRENDA; MORAN, GARY; COLEMAN, DAVID (2009)When Candida dubliniensis isolates obtained from seabird excrement and from humans in Ireland were compared by using multilocs sequence typing, 13 of 14 avian isolates were genetically distinct from human isolates. The ... -
AZOLE SUSCEPTIBILITY AND RESISTANCE IN CANDIDA DUBLINIENSIS
SULLIVAN, DEREK; MORAN, GARY; COLEMAN, DAVID (2005)Candida dubliniensis is a recently described species of pathogenic yeast that shares many phenotypic features with Candida albicans. It is primarily associated with oral colonization and infection in HIV-infected individuals. ... -
CANDIDA ALBICANS VERSUS CANDIDA DUBLINIENSIS: WHY IS C. ALBICANS MORE PATHOGENIC?
COLEMAN, DAVID; SULLIVAN, DEREK; MORAN, GARY (2012)Candida albicans and Candida dubliniensis are highly related pathogenic yeast species. However, C. albicans is far more prevalent in human infection and has been shown to be more pathogenic in a wide range of infection ... -
The Candida albicans-Specific Gene EED1 Encodes a Key Regulator of Hyphal Extension
SULLIVAN, DEREK; MORAN, GARY (2011)The extension of germ tubes into elongated hyphae by Candida albicans is essential for damage of host cells. The C. albicans-specific gene EED1 plays a crucial role in this extension and maintenance of filamentous growth. ... -
Candida dubliniensis: An update
SHANLEY, DIARMUID; MORAN, GARY; MC CARTAN, BERNARD; COLEMAN, DAVID; SULLIVAN, DEREK (Revista Iberoamericana de Micologia, 1999)The increased incidence of fungal infections during the last decade has been well-documented. Given that one of the most important factors contributing to this phenomenon is the increased numbers of immunocompromised ... -
COMPARATIVE ADHERENCE OF CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS TO HUMAN BUCCAL EPITHELIAL CELLS AND EXTRACELLULAR MATRIX PROTEINS
SULLIVAN, DEREK; COLEMAN, DAVID; MORAN, GARY (2014)Candida albicans and Candida dubliniensis are very closely related pathogenic yeast species. Despite their close relationship, the former is a far more successful coloniser and pathogen of humans. The purpose of the current ... -
COMPARATIVE GENOMICS AND THE EVOLUTION OF PATHOGENICITY IN HUMAN PATHOGENIC FUNGI
SULLIVAN, DEREK; COLEMAN, DAVID; MORAN, GARY (2011)Because most fungi have evolved to be free-living in the environment and because the infections they cause are usually opportunistic in nature, it is often difficult to identify specific traits that contribute to fungal ... -
COMPARATIVE GENOMICS USING CANDIDA ALBICANS DNA MICROARRAYS REVEALS ABSENCE AND DIVERGENCE OF VIRULENCE ASSOCIATED GENES IN CANDIDA DUBLINIENSIS
SULLIVAN, DEREK; COLEMAN, DAVID; MORAN, GARY (2004)Candida dubliniensis is a pathogenic yeast species closely related to Candida albicans. However, it is less frequently associated with human disease and displays reduced virulence in animal models of infection. We have ... -
COMPARATIVE TRANSCRIPT PROFILING OF Candida albicans AND Candida dubliniensis IDENTIFIES SFL2, A C. albicans GENE REQUIRED FOR VIRULENCE IN A RECONSTITUTED EPITHELIAL INFECTION MODEL
HIGGINS, JUDY; SULLIVAN, DEREK; COLEMAN, DAVID; MORAN, GARY (2010)Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. ... -
Differential filamentation of Candida albicans and C. dubliniensis is governed by nutrient regulation of UME6 expression
SULLIVAN, DEREK (American Society for Microbiology, 2010)Candida dubliniensis is closely related to C. albicans, however it is responsible for fewer infections in humans and is less virulent in animal models of infection. C. dubliniensis forms fewer hyphae in vivo and this may ... -
DIFFERENTIAL REGULATION OF THE TRANSCRIPTIONAL REPRESSOR NRG1 ACCOUNTS FOR ALTERED HOST CELL INTERACTIONS IN CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS
COLEMAN, DAVID; SULLIVAN, DEREK; MORAN, GARY (2007)Candida dubliniensis is genetically closely related to C. albicans, but causes fewer infections in humans and exhibits reduced virulence and filamentation in animal models of infection. We investigated the role of the ... -
DIFFERENTIAL REGULATION OF THE TRANSCRIPTIONAL REPRESSOR NRG1 ACCOUNTS FOR ALTERED HOST CELL INTERACTIONS IN CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS
COLEMAN, DAVID; MORAN, GARY; SULLIVAN, DEREK; COLEMAN, DAVID; MORAN, GARY (Blackwell Publishing, 2007-09)Candida dubliniensis is genetically closely related to C. albicans, but causes fewer infections in humans and exhibits reduced virulence and filamentation in animal models of infection. We investigated the role of the C. ... -
DIFFERENTIAL VIRULENCE OF CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS: A ROLE FOR TOR KINASE?
SULLIVAN, DEREK; MORAN, GARY (2011)Candida albicans and Candida dubliniensis are two very closely related species of pathogenic yeast. C. albicans is the most prevalent species in the human gastrointestinal tract and is responsible for far more opportunistic ... -
Emergence of Sequence Type 779 Methicillin-Resistant Staphylococcus aureus (MRSA) Harboring a Novel Pseudo Staphylococcal Cassette Chromosome mec (SCCmec)-SCC-SCCCRISPR Composite Element in Irish Hospitals.
KINNEVEY, PETER; SULLIVAN, DEREK (2013)Methicillin-resistant Staphylococcus aureus (MRSA) has been a major cause of nosocomial infection in Irish hospitals for 4 decades, and replacement of predominant MRSA clones has occurred several times. An MRSA isolate ... -
EXTENSIVE GENETIC DIVERSITY IDENTIFIED AMONG SPORADIC METHICILLIN-RESISTANT Staphylococcus aureus ISOLATES RECOVERED IN IRISH HOSPITALS BETWEEN 2000-2012
COLEMAN, DAVID; SULLIVAN, DEREK; SHORE, ANNA (2014)Clonal replacement of predominant nosocomial methicillin-resistant Staphylococcus aureus (MRSA) strains has occurred several times in Ireland during the last four decades. However, little is known about sporadically-occurring ... -
Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress
Enjalbert, Brice; Moran, Gary; Vaughan, Claire; Yeomans, Tim; MacCallum, Donna; Quinn, Janet; Coleman, David; Brown, Alistair; SULLIVAN, DEREK (Wiley-Blackwell, 2009)Candida albicans is more pathogenic than Candida dubliniensis. However, this disparity in virulence is surprising given the high level of sequence conservation and the wide range of phenotypic traits shared by these two ... -
Global Transcriptome Sequencing Identifies Chlamydospore Specific Markers in Candida albicans and Candida dubliniensis.
SULLIVAN, DEREK (2013)Candida albicans and Candida dubliniensis are pathogenic fungi that are highly related but differ in virulence and in some phenotypic traits. During in vitro growth on certain nutrient-poor media, C. albicans and C. ... -
Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans
COLEMAN, D.C.; STOKES, C.; MORAN, G.P; SPIERING, M.J.; SULLIVAN, DEREK (Elsevier, 2007)Candida albicans and Candida dubliniensis are very closely related yeast species. In this study, we have conducted a thorough comparison of the ability of the two species to produce hyphae and their virulence in two ... -
MICROBIOLOGICAL SCREENING OF IRISH AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY (APECED) PATIENTS REVEALS PERSISTENCE OF CANDIDA ALBICANS STRAINS, GRADUAL REDUCTION IN SUSCEPTIBILITY TO AZOLES AND INCIDENCES OF CLINICAL SIGNS OF ORAL CANDIDIASIS WITHOUT CULTURE EVIDENCE
MORAN, GARY; MC MANUS, BRENDA; SULLIVAN, DEREK; HEALY, CLAIRE; NUNN, JUNE; COLEMAN, DAVID; FLEMING, PADRAIG (2011)Patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) are prone to chronic mucocutaneous candidiasis, which is often treated with azoles. The purpose of this study was to characterize the ...