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  • Dissociation of activated protein C functions by elimination of protein S cofactor enhancement. 

    HARMON, SHONA; PRESTON, ROGER; O'DONNELL, JAMES; NI AINLE, FIONNUALA; JOHNSON, JENNIFER (American Society for Biochemistry and Molecular Biology, 2008)
    Activated protein C (APC) plays a critical anticoagulant role in vivo by inactivating procoagulant factor Va and factor VIIIa and thus down-regulating thrombin generation. In addition, APC bound to the endothelial cell ...
  • Platelet factor 4 impairs the anticoagulant activity of activated protein C. 

    HARMON, SHONA; PRESTON, ROGER; JOHNSON, JENNIFER; O'DONNELL, JAMES; NI AINLE, FIONNUALA (American Society for Biochemistry and Molecular Biology, 2009)
    Platelet factor 4 (PF4) is an abundant platelet -granule chemokine released following platelet activation. PF4 interacts with thrombomodulin and the -carboxyglutamic acid (Gla) domain of protein C, thereby enhancing ...