Browsing by Author "O'NEILL, LUKE ANTHONY JOHN"
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Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity
MILLS, KINGSTON; O'NEILL, LUKE ANTHONY JOHN (The American Association of Immunologists, 2000)We have examined the roles of enzyme activity and the nontoxic AB complex of heat-labile toxin (LT) from Escherichia coli on its adjuvant and immunomodulatory properties. LTK63, an LT mutant that is completely devoid of ... -
The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 2004)The interleukin-1 receptor-associated kinases (IRAKs) are important downstream signaling components of Toll-like receptors (TLRs). To date, four mammalian IRAKs have been found, namely IRAK-1, IRAK-2, IRAK-4, and IRAK-M. ... -
Mycobacterial PIMs Inhibit Host Inflammatory Responses through CD14-Dependent and CD14-Independent Mechanisms
O'NEILL, LUKE ANTHONY JOHN; KENNY, ELAINE (2011)Mycobacteria develop strategies to evade the host immune system. Among them, mycobacterial LAM or PIMs inhibit the expression of pro-inflammatory cytokines by activated macrophages. Here, using synthetic PIM analogues, we ... -
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
O'NEILL, LUKE ANTHONY JOHN; DUNNE, AISLING (2006)Members of the Toll-like receptor (TLR) family are essential players in activating the host innate immune response against infectious microorganisms. All TLRs signal through Toll/interleukin 1 receptor domain-containing ... -
Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody.
O'NEILL, LUKE ANTHONY JOHN (2010)Background?Reperfusion therapy for myocardial infarction is hampered by detrimental inflammatory responses partly via Toll-like receptor (TLR) activation. Targeting TLR signaling may optimize reperfusion therapy and enhance ... -
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
MCGETTRICK-DILLON, ANNE; O'NEILL, LUKE ANTHONY JOHN (National Academy of Sciences, 2006)TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively in the TLR4 pathway. ... -
New insights into the regulation of TLR signaling
O'NEILL, LUKE ANTHONY JOHN (Society of Leukocyte Biology, 2006)Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and the signal transduction ... -
NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1
O'NEILL, LUKE ANTHONY JOHN; PALSSON MCDERMOTT, EVA; BANAHAN, KATHY; DUNNE, AISLING (2007)Toll-like receptors (TLRs)-2 and -4 are important proteins in innate immunity, recognizing microbial products and eliciting host defense responses. Both use the adapter proteins MyD88 and MyD88 adapter-like (Mal) to activate ... -
Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion
O'NEILL, LUKE ANTHONY JOHN; CREAGH, EMMA (2009)IL-1? is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic ... -
Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression
O'NEILL, LUKE ANTHONY JOHN (American Society for Biochemistry and Molecular Biology, 2000)We have examined the involvement of Rac1 in nuclear factor kappaB (NFkappaB) activation by interleukin 1 (IL1). IL1 induced a rapid and sustained activation of Rac1 in the thymoma cell line EL4.NOB-1. Transient transfection ... -
Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
O'NEILL, LUKE ANTHONY JOHN (American Society for Biochemistry and Molecular Biology, 2002)Interleukin-1 (IL-1) activates p38 MAP kinase via the small G protein Ras, and this activity can be down-regulated by another small G protein Rap. Here we have further investigated the role of Ras and Rap in p38 MAPK ... -
Resolution of inflammation: state of the art, definitions and terms
O'NEILL, LUKE ANTHONY JOHN (The Federation of American Societies for Experimental Biology., 2006)A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28, 2006, organized by D.W. Gilroy and S.D. Brain for the British Pharmacology Society. We concluded at the meeting that a consensus ... -
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
O'NEILL, LUKE ANTHONY JOHN; PALSSON, EVA (British Society for Immunology, 2004)An understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress ... -
Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.
O'NEILL, LUKE ANTHONY JOHN (Society of Leukocyte Biology, 1998)Interleukin-1 (IL-1) is a central regulator of the immune and inflammatory responses. Recently, significant advances have been made in the area of IL-1 receptors and IL-1 signal transduction. A family of proteins has been ... -
Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.
FEIGHERY, CONLETH FRANCIS; DOYLE, SARAH LOUISE; O'NEILL, LUKE ANTHONY JOHN (2007)Toll-like receptors (TLRs) are a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. TLR7 and TLR8 sense single-stranded RNA from viruses or host ribonucleoproteins ... -
Signalling via CD28 of human naive neonatal T lymphocytes.
O'NEILL, LUKE ANTHONY JOHN (British Society for Immunology, 1995)Accessory molecules play a crucial role in the development of the T cell response to antigenic challenge. We have examined the role of CD28 in modulating the 'naive' neonatal T cell response to anti-CD2-mediated activation. ... -
Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.
O'NEILL, LUKE ANTHONY JOHN (Portland Press, 1997)Protein kinase C (PKC) has been implicated in interleukin 1 (IL1) signal transduction in a number of cellular systems, either as a key event in IL1 action or as a negative regulator. Here we have examined the effects of ... -
Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88
O'NEILL, LUKE ANTHONY JOHN; DUNNE, AISLING (2003)The Toll/interleukin 1 receptor (TIR) domain is a region found in the cytoplasmic tails of members of the Toll-like receptor/interleukin-1 receptor superfamily. The domain is essential for signaling and is also found in ... -
Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit.
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 1995)The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat ... -
TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control ras-dependent amplification of NF-?B
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 2010)Host defense against infection is induced by Toll-like and interleukin (IL)-1 receptors, and controlled by the transcription factor NF-?B. Our earlier studies have shown that IL-1 activation impacts cytoskeletal structure ...