Browsing by Author "NI AINLE, FIONNUALA"
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Dissociation of activated protein C functions by elimination of protein S cofactor enhancement.
PRESTON, ROGER; O'DONNELL, JAMES; JOHNSON, JENNIFER; HARMON, SHONA; NI AINLE, FIONNUALA (2008)Activated protein C (APC) plays a critical anticoagulant role in vivo by inactivating procoagulant factor Va and factor VIIIa and thus down-regulating thrombin generation. In addition, APC bound to the endothelial cell ... -
Platelet factor 4 impairs the anticoagulant activity of activated protein C.
PRESTON, ROGER; HARMON, SHONA; NI AINLE, FIONNUALA; O'DONNELL, JAMES; JOHNSON, JENNIFER (2009)Platelet factor 4 (PF4) is an abundant platelet -granule chemokine released following platelet activation. PF4 interacts with thrombomodulin and the -carboxyglutamic acid (Gla) domain of protein C, thereby enhancing ...