Browsing by Author "MORRIS, DEREK"
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Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.
QUINN, EMMA; KENNY, ELAINE; CORVIN, AIDEN; GILL, MICHAEL; MORRIS, DEREK (2010)Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases, such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes with specific brain functions. Under these ... -
Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility
DONOHOE, GARY; MORRIS, DEREK; GILL, MICHAEL (2014) -
Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.
MORRIS, DEREK; CORVIN, AIDEN PETER; GILL, MICHAEL (2009)We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 SNPs mapping to 10q25-q26 that ... -
Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample.
MORRIS, DEREK; BRADLEY, DANIEL; DONOHOE, GARY; GILL, MICHAEL; CORVIN, AIDEN; FAHEY, CIARA; HARDIMAN, ORLA; MCLAUGHLIN, RUSSELL (2014)The hexonucleotide repeat expansion 'GGGGCC' at the C9ORF72 gene has been strongly linked with amyotrophic lateral sclerosis and frontotemporal dementia. There is some evidence for clinical and genetic overlap between ... -
Assessment of Inactivating Stop Codon Mutations in Forty Saccharomyces cerevisiae Strains: Implications for [PSI] Prion- Mediated Phenotypes.
KENNY, ELAINE; MORRIS, DEREK; CORMICAN, PAUL (2011)The yeast prion [PSI+] has been implicated in the generation of novel phenotypes by a mechanism involving a reduction in translation fidelity causing readthrough of naturally occurring stop codons. Some [PSI+] associated ... -
Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing.
MORRIS, DEREK; O'FARRELLY, CLIONA; BRADLEY, DANIEL; KENNY, ELAINE (2012)Campylobacter jejuni is the most common cause of human bacterial gastroenteritis and is associated with several post-infectious manifestations, including onset of the autoimmune neuropathy Guillain-Barre syndrome, causing ... -
Clinical symptomatology and the psychosis risk gene, ZNF804A
CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK; GILL, MICHAEL (2010)The single nucleotide polymorphism (SNP) rs1344706, mapping to the gene ZNF804A, has been implicated in schizophrenia susceptibility ([O'Donovan et al., 2008], [International Schizophrenia Consortium, 2009], [Stefansson ... -
CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1.
CORVIN, AIDEN; MORRIS, DEREK; GILL, MICHAEL (2014) -
Common variant at 16p11.2 conferring risk of psychosis
MORRIS, DEREK; GILL, MICHAEL (2012)Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18?206 ... -
Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing
MORRIS, DEREK; MCLAUGHLIN, RUSSELL (2013) -
Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing.
HARDIMAN, ORLA; CORVIN, AIDEN; MORRIS, DEREK; MCLAUGHLIN, RUSSELL; KENNY, ELAINE (2013) -
Development of Strategies for SNP Detection in RNA-Seq Data: Application to Lymphoblastoid Cell Lines and Evaluation Using 1000 Genomes Data.
MORRIS, DEREK; ANNEY, RICHARD JAMES LEON; CORVIN, AIDEN PETER; GILL, MICHAEL (2013)Next-generation RNA sequencing (RNA-seq) maps and analyzes transcriptomes and generates data on sequence variation in expressed genes. There are few reported studies on analysis strategies to maximize the yield of quality ... -
DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: A study in depressed patients and healthy controls
FRODL, THOMAS; GILL, MICHAEL; MORRIS, DEREK; MEANEY, JAMES; MEANEY, JAMES; FRODL, THOMAS; MORRIS, DEREK; GILL, MICHAEL (2015)Serotonin plays an important role in the etiology of depression. Serotonin is also crucial for brain development. For instance, animal studies have demonstrated that early disruptions in the serotonin system affect brain ... -
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2011)Rare copy number variants (CNVs) play a prominent role in the etiology of schizophrenia and other neuropsychiatric disorders 1 . Substantial risk for schizophrenia is conferred by large (>500 kb) CNVs at several loci, ... -
Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia
ROBERTSON, IAN; GILL, MICHAEL; MORRIS, DEREK; GARAVAN, HUGH; CORVIN, AIDEN; FOXE, JOHN (2008)Background: Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. ... -
Effect of genetic variant in BICCI on functional and structural brain changes in depression
GILL, MICHAEL; DONOHOE, GARY; FAGAN, ANDREW; MORRIS, DEREK; FRODL, THOMAS (2012) -
The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function.
MORRIS, DEREK; MC GRATH, JANE; ROBERTSON, IAN H; NEWELL, FIONA; O'DOHERTY, JOHN PHILIP; GILL, MICHAEL; TROPEA, DANIELA; DONOHOE, GARY (JAMES); CORVIN, AIDEN PETER; GARAVAN, HUGH PATRICK; BOKDE, ARUN LAWRENCE WARREN (2012)A single nucleotide polymorphism rs12807809 located upstream of the neurogranin (NRGN) gene has been identified as a risk variant for schizophrenia in recent genome-wide association studies. To date, there has been little ... -
Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style.
MORRIS, DEREK; DONOHOE, GARY; HARGREAVES, APRIL; GILL, MICHAEL; FAHEY, CIARA; CORVIN, AIDEN; TROPEA, DANIELA (2014)BACKGROUND: A single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2) gene was recently identified as a common risk variant for schizophrenia. The mechanism by which CNNM2 confers risk is unknown. AIMS: To ... -
Effects of MIR137 on fronto-amygdala functional connectivity.
FAHEY, CIARA; MORRIS, DEREK; KELLY, SINEAD; GILL, MICHAEL; DONOHOE, GARY; REILLY, RICHARD; CORVIN, AIDEN (2014)MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with ...