Browsing by Author "MORRIS, DEREK"
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Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia
ROBERTSON, IAN; GILL, MICHAEL; MORRIS, DEREK; GARAVAN, HUGH; CORVIN, AIDEN; FOXE, JOHN (2008)Background: Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. ... -
Effect of genetic variant in BICCI on functional and structural brain changes in depression
GILL, MICHAEL; DONOHOE, GARY; FAGAN, ANDREW; MORRIS, DEREK; FRODL, THOMAS (2012) -
The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function.
MORRIS, DEREK; MC GRATH, JANE; ROBERTSON, IAN H; NEWELL, FIONA; O'DOHERTY, JOHN PHILIP; GILL, MICHAEL; TROPEA, DANIELA; DONOHOE, GARY (JAMES); CORVIN, AIDEN PETER; GARAVAN, HUGH PATRICK; BOKDE, ARUN LAWRENCE WARREN (2012)A single nucleotide polymorphism rs12807809 located upstream of the neurogranin (NRGN) gene has been identified as a risk variant for schizophrenia in recent genome-wide association studies. To date, there has been little ... -
Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style.
MORRIS, DEREK; DONOHOE, GARY; HARGREAVES, APRIL; GILL, MICHAEL; FAHEY, CIARA; CORVIN, AIDEN; TROPEA, DANIELA (2014)BACKGROUND: A single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2) gene was recently identified as a common risk variant for schizophrenia. The mechanism by which CNNM2 confers risk is unknown. AIMS: To ... -
Effects of MIR137 on fronto-amygdala functional connectivity.
FAHEY, CIARA; MORRIS, DEREK; KELLY, SINEAD; GILL, MICHAEL; DONOHOE, GARY; REILLY, RICHARD; CORVIN, AIDEN (2014)MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with ... -
Effects of ZNF804A on auditory P300 response in schizophrenia.
GILL, MICHAEL; CORVIN, AIDEN; DONOHOE, GARY; MORRIS, DEREK; TROPEA, DANIELA (2014) -
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
MORRIS, DEREK; DONOHOE, GARY (2014) -
Evaluation of a Susceptibility Gene for Schizophrenia: Genotype Based Meta-Analysis of RGS4 Polymorphisms from Thirteen Independent Samples
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2006) -
Evidence that duplications of 22q11.2 protect against schizophrenia.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK (2014)A number of large, rare copy number variants (CNVs) are deleterious for neurodevelopmental disorders, but large, rare, protective CNVs have not been reported for such phenotypes. Here we show in a CNV analysis of 47 005 ... -
Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders.
CORVIN, AIDEN; HERON, ELIZABETH; GILL, MICHAEL; DONOHOE, GARY; ANNEY, RICHARD; GALLAGHER, LOUISE; MORRIS, DEREK; TROPEA, DANIELA; KENNY, ELAINE (2014) -
Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder.
GILL, MICHAEL; HARKIN, ANDREW; MORRIS, DEREK; O'KEANE, VERONICA (2014) -
Fine mapping of ZNF804A and genomime-wide significant evidence for it's involvement in Schizophrenia and bipolar disorder.
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; QUINN, EMMA (2011)A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the ... -
Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.
GILL, MICHAEL; MORRIS, DEREK; KENNY, ELAINE; CORVIN, AIDEN (2012)Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of _1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated ... -
Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia
GILL, MICHAEL; DONOHOE, GARY; CORVIN, AIDEN; MORRIS, DEREK; FRODL, THOMAS (2016)Background: Resting-state functional magnetic resonance imaging (rs-fMRI) has repeatedly shown evidence of altered functional connectivity of large-scale networks in schizophrenia. The relationship between these connectivity ... -
Genetic Classification of Populations using Supervised Learning.
GILL, MICHAEL; MORRIS, DEREK; HERON, ELIZABETH; CORVIN, AIDEN; PINTO, CARLOS (2011)There are many instances in genetics in which we wish to determine whether two candidate populations are distinguishable on the basis of their genetic structure. Examples include populations which are geographically ... -
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL (2013) -
Genome-wide association study identifies five new schizophrenia loci.
MORRIS, DEREK; CORVIN, AIDEN PETER; GILL, MICHAEL; DONOHOE, GARY (JAMES) (2011)We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication ... -
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.
MORRIS, DEREK; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER (2012)Background? We performed a genome-wide association study (GWAS) to identify common risk variants for schizophrenia. Methods? The discovery scan included 1606 patients and 1794 controls from Ireland, using 6,212,339 ...